ChemicalBook > CAS DataBase List > (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

Product Name
(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
CAS No.
1415407-60-1
Chemical Name
(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
Synonyms
TC-G 1005;TC-G 1005, 10 mM in DMSO;TGR5 Receptor Agonist, Cpd23g;(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone;Methanone, (4-cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]-;TC G 1005,G protein-coupled Bile Acid Receptor 1,levels,coupled,glucose,TCG 1005,Takeda,inhibit,protein,TC-G 1005,GPBAR1,GPCR19,TGR5,Inhibitor,G-protein coupled receptor 19
CBNumber
CB12717284
Molecular Formula
C25H25N3O2
Formula Weight
399.48
MOL File
1415407-60-1.mol
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(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone Property

Boiling point:
564.5±50.0 °C(Predicted)
Density 
1.253±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
6.35±0.20(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05854
Product name
TGR5 Receptor Agonist, Cpd23g
Packaging
10 mg
Price
$259
Updated
2025/07/31
Tocris
Product number
5129
Product name
TC-G1005
Purity
≥98%(HPLC)
Packaging
50
Price
$971
Updated
2021/12/16
Tocris
Product number
5129
Product name
TC-G1005
Purity
≥98%(HPLC)
Packaging
10
Price
$231
Updated
2021/12/16
TRC
Product number
T012505
Product name
TC-G1005
Packaging
5mg
Price
$115
Updated
2021/12/16
Usbiological
Product number
466884
Product name
TC-G 1005
Packaging
5mg
Price
$403
Updated
2021/12/16
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(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone Chemical Properties,Usage,Production

Uses

TC-G 1005 is an agonist required for the activation of Takeda G-protein receptor 5 (TGR5).

Biological Activity

Primary Target
TGR5', 'Reversible: yes

in vivo

TC-G 1005 (25-100 mg/kg; a single p.o.) stimulates GLP-1 secretion in imprinting control region (ICR) mice[1].
? TC-G 1005 (50 mg/kg; a single p.o.) causes a 49% reduction in blood glucose AUC0-120 min in ICR mice[1].
? TC-G 1005 (50 mg/kg; a single p.o.) signi?cantly reduces blood glucose at 4, 6, 10, and 24 h in db/db mice[1].
? TC-G 1005 (5 mg/kg; p.o.) exhibits rather low plasma exposure, with a Cmax of 56 ng/mL and a t1/2 of 1.5 in rats[1].

Animal Model:Male ICR mice[1]
Dosage:25, 50, 100 mg/kg
Administration:A single p.o.
Result:Increased the plasma active GLP-1 levels by 31, 96, and 282% at doses of 25, 50, and 100 mg/kg, respectively.

storage

Store at -20°C

(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone Suppliers

China 23 United Kingdom 1 United States 4 USA 1 Global 29
Tocris Bioscience
Tel
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Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
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1415407-60-1, (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanoneRelated Search:

Sodium cyanoborohydride

  • (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
  • TC-G 1005
  • Methanone, (4-cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]-
  • TC G 1005,G protein-coupled Bile Acid Receptor 1,levels,coupled,glucose,TCG 1005,Takeda,inhibit,protein,TC-G 1005,GPBAR1,GPCR19,TGR5,Inhibitor,G-protein coupled receptor 19
  • TC-G 1005, 10 mM in DMSO
  • TGR5 Receptor Agonist, Cpd23g
  • 1415407-60-1