Secukinumab
- Product Name
- Secukinumab
- CAS No.
- 1229022-83-6
- Chemical Name
- Secukinumab
- Synonyms
- AIN457;AIN 457;AIN-457;Secukinumab;Secukinumab (anti-IL-17A);Research Grade Secukinumab;Research Grade Secukinumab(DHH28802)
- CBNumber
- CB12744217
- Formula Weight
- 0
- MOL File
- Mol file
Secukinumab Property
- form
- Liquid
- color
- Colorless to light yellow
- CAS DataBase Reference
- 1229022-83-6
Secukinumab Chemical Properties,Usage,Production
Uses
Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis[1][2].
Clinical Use
Human IgG1/κ monoclonal antibody:
Treatment of moderate to severe plaque psoriasis,
psoriatic arthritis, ankylosing spondylitis
Drug interactions
Potentially hazardous interactions with other drugs
Vaccines: risk of generalised infections with live
vaccines - avoid.
IC 50
IL-17A
Metabolism
The majority of IgG elimination occurs via intracellular catabolism, following fluid-phase or receptor mediated endocytosis.
References
[1] Shirley M, et al. Secukinumab: A Review in Psoriatic Arthritis. Drugs. 2016;76(11):1135-1145. DOI:10.1007/s40265-016-0602-3
[2] Reich K, et al. Secukinumab dosing optimization in patients with moderate-to-severe plaque psoriasis: results from the randomized, open-label OPTIMISE study. Br J Dermatol. 2020;182(2):304-315. DOI:10.1007/s40265-016-0602-3
[3] Elain G, et al. The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes. Glia. 2014;62(5):725-735. DOI:10.1002/glia.22637
Secukinumab Preparation Products And Raw materials
Raw materials
Preparation Products
Secukinumab Suppliers
- Tel
- 27-027-83314682 13554138826
- Fax
- +86 (27) 8331-4682
- whsrtech@vip.163.com
- Country
- China
- ProdList
- 246
- Advantage
- 62
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 021-54285032 13641685631
- Fax
- +86 (21) 5443 7651
- gerry.shu@hanjingchemicals.com
- Country
- China
- ProdList
- 76
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2989
- Advantage
- 58
- Tel
- +86-0551-62678551 +86-15056975894
- Fax
- 05512678551
- sales@hirisunpharm.com
- Country
- China
- ProdList
- 176
- Advantage
- 55
- Tel
- +86-0576-88813233 +86-13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10237
- Advantage
- 58
- Tel
- +8615056975894
- Fax
- 86-0551-62678551
- shawn@hirisunpharm.com
- Country
- CHINA
- ProdList
- 9911
- Advantage
- 58
- Tel
- 86 18062405514 18062405514
- ada@ipurechemical.com
- Country
- CHINA
- ProdList
- 3461
- Advantage
- 58
- Tel
- 15817493340
- 981810490@qq.com
- Country
- China
- ProdList
- 1566
- Advantage
- 58
- Tel
- 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4686
- Advantage
- 58
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
- 422450190@qq.com
- Country
- China
- ProdList
- 10308
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 18171815831
- 1341138380@qq.com
- Country
- China
- ProdList
- 4310
- Advantage
- 58
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
- Country
- China
- ProdList
- 9868
- Advantage
- 58
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 6614
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 17721492509; 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 4969
- Advantage
- 58
- Tel
- 0731-13823398 15111215862
- 313359644@qq.com
- Country
- China
- ProdList
- 4161
- Advantage
- 58
- Tel
- 17316404525 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9766
- Advantage
- 58
- Tel
- 0573-83568680 18057391398
- 3956524501@qq.com
- Country
- China
- ProdList
- 1442
- Advantage
- 58
- Tel
- 025-58851090 17714375163
- 2881759498@qq.com
- Country
- China
- ProdList
- 13011
- Advantage
- 58
- Tel
- 027-87008169 17762441161
- info@atagenix.com
- Country
- China
- ProdList
- 10001
- Advantage
- 58
- Tel
- 33175446423
- support@antibodysystem.com
- Country
- China
- ProdList
- 6739
- Advantage
- 58
- Tel
- 400-668-6834
- info@selleck.cn
- Country
- China
- ProdList
- 6071
- Advantage
- 58
- Tel
- 9785721070
- info@cellsciences.com
- Country
- China
- ProdList
- 6308
- Advantage
- 58
- Tel
- 18672314556 +8618672314556
- sales@kdg-tech.com
- Country
- China
- ProdList
- 933
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8467
- Advantage
- 58
- Tel
- Country
- China
- ProdList
- 995
- Advantage
- 58
- Tel
- 13760798286
- Country
- CHINA
- ProdList
- 188
- Advantage
- 58
- Tel
- 17765667235
- Country
- CHINA
- ProdList
- 129
- Advantage
- 58
- Tel
- 18689410811
- Country
- CHINA
- ProdList
- 178
- Advantage
- 58
- Tel
- 18926165828
- Country
- CHINA
- ProdList
- 198
- Advantage
- 58
- Tel
- 18312220236
- Country
- CHINA
- ProdList
- 178
- Advantage
- 58
- Tel
- 17765276361
- Country
- CHINA
- ProdList
- 109
- Advantage
- 58