4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid

Product Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
CAS No.: 215307-86-1
Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
Synonyms: BMS 753, 10 mM in DMSO;BMS 753, RARalpha agonist;4-(1,1,3,3-tetramethyl-2-oxo-2,3-dihydro-1H-indene-5-amido)benzoic acid;4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate;Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-
CBNumber: CB12750575
Molecular Formula: C21H21NO4
Formula Weight: 351.4
MOL File: 215307-86-1.mol

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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Property

Boiling point:: 482.2±45.0 °C(Predicted)
Density: 1.240±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
pka: 4.26±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0286
Product name: BMS 753
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $84.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0286
Product name: BMS 753
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $510
Updated: 2023/01/07

Cayman Chemical

Product number: 29493
Product name: BMS 753
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29493
Product name: BMS 753
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29493
Product name: BMS 753
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Chemical Properties,Usage,Production

Uses

BMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery.

Biological Activity

BMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα.

in vitro

BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ ^-/- , but not activates in RARa ^-/- cells.

target

RARα

storage

Store at RT

4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Suppliers

China 25 United Kingdom 1 United States 8 USA 1 Global 35

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215307-86-1, 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acidRelated Search:

Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-

4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate

4-(1,1,3,3-tetramethyl-2-oxo-2,3-dihydro-1H-indene-5-amido)benzoic acid

BMS 753, RARalpha agonist

BMS 753, 10 mM in DMSO

215307-86-1