ChemicalBook > CAS DataBase List > 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid

4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid

Product Name
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
CAS No.
215307-86-1
Chemical Name
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
Synonyms
BMS 753, 10 mM in DMSO;BMS 753, RARalpha agonist;4-(1,1,3,3-tetramethyl-2-oxo-2,3-dihydro-1H-indene-5-amido)benzoic acid;4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate;Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-
CBNumber
CB12750575
Molecular Formula
C21H21NO4
Formula Weight
351.4
MOL File
215307-86-1.mol
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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Property

Boiling point:
482.2±45.0 °C(Predicted)
Density 
1.240±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
pka
4.26±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0286
Product name
BMS 753
Purity
≥98% (HPLC)
Packaging
5mg
Price
$84.7
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0286
Product name
BMS 753
Purity
≥98% (HPLC)
Packaging
25mg
Price
$510
Updated
2023/01/07
Cayman Chemical
Product number
29493
Product name
BMS 753
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29493
Product name
BMS 753
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29493
Product name
BMS 753
Packaging
10mg
Price
$169
Updated
2024/03/01
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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Chemical Properties,Usage,Production

Uses

BMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery.

Biological Activity

BMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα.

in vitro

BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ -/- , but not activates in RARa -/- cells.

target

RARα

storage

Store at RT

4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Suppliers

China 25 United Kingdom 1 United States 8 USA 1 Global 35
EMMX Biotechnology LLC
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215307-86-1, 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acidRelated Search:


  • Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-
  • 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate
  • 4-(1,1,3,3-tetramethyl-2-oxo-2,3-dihydro-1H-indene-5-amido)benzoic acid
  • BMS 753, RARalpha agonist
  • BMS 753, 10 mM in DMSO
  • 215307-86-1