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NSC 150117 hydrochloride

Product Name
NSC 150117 hydrochloride
CAS No.
95130-23-7
Chemical Name
NSC 150117 hydrochloride
Synonyms
(E/Z)-BCI;BCI (hydrochloride);(E)-BCI hydrochloride;(E/Z)-BCI hydrochloride;NSC 150117 hydrochloride;BCI hydrochloride - NSC 150117 hydrochloride;(2Z)-2-benzylidene-3-(cyclohexylamino)-3H-inden-1-one;2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride;(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one;3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one
CBNumber
CB12756032
Molecular Formula
C22H24ClNO
Formula Weight
353.885
MOL File
95130-23-7.mol
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NSC 150117 hydrochloride Property

storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B4313
Product name
(E/Z)-BCI hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$254
Updated
2025/07/31
Sigma-Aldrich
Product number
B4313
Product name
(E/Z)-BCI hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$695.1
Updated
2025/07/31
Cayman Chemical
Product number
21945
Product name
BCI (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21945
Product name
BCI (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
21945
Product name
BCI (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$384
Updated
2024/03/01
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NSC 150117 hydrochloride Chemical Properties,Usage,Production

Uses

(E/Z)-BCI hydrochloride has been used:

  • to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regeneration
  • as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
  • as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells

Biochem/physiol Actions

BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.

NSC 150117 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 150117 hydrochloride Suppliers

China 25 United States 8 Global 33
Sigma-Aldrich
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Changzhou Chenhong Biotechnology Co., Ltd.
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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TargetMol Chemicals Inc.
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RD International Technology Co., Limited
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TargetMol Chemicals Inc.
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Cayman Chemical Company
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Merck KGaA
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95130-23-7, NSC 150117 hydrochlorideRelated Search:


  • (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
  • (E/Z)-BCI hydrochloride
  • 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride
  • 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one
  • NSC 150117 hydrochloride
  • BCI (hydrochloride)
  • (E/Z)-BCI
  • BCI hydrochloride - NSC 150117 hydrochloride
  • (2Z)-2-benzylidene-3-(cyclohexylamino)-3H-inden-1-one
  • (E)-BCI hydrochloride
  • 95130-23-7