RO-31-7549

Product Name: RO-31-7549
CAS No.: 125313-65-7
Chemical Name: RO-31-7549
Synonyms: RO-31-7549;RO 31-7549 ACETATE SALT;Bisindolylmaleimide VIII;BISINDOLYLMALEIMIDE VIII ACETATE;BIDINDOLYLMALEIMIDE VIII, ACETETE;Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
CBNumber: CB1281637
Molecular Formula: C24H22N4O2
Formula Weight: 398.46
MOL File: 125313-65-7.mol

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RO-31-7549 Property

storage temp.: −20°C
solubility: DMSO: soluble
form: Red to reddish-orange solid

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 557508
Product name: Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem<br />A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.
Packaging: 1mg
Price: $216
Updated: 2024/03/01

Usbiological

Product number: 044608
Product name: Bisindolylmaleimide VIII acetate
Packaging: 1mg
Price: $286
Updated: 2021/12/16

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RO-31-7549 Chemical Properties,Usage,Production

Uses

It is a potent inhibitor of protein kinase C (PKC) activity.

General Description

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ₁. Exhibits some degree of PKC isozyme specificity (IC₅₀ = 53 nM for PKC_α, 195 nM for PKC_βI, 163 nM for PKC_βII, 213 nM for PKC_γ, and 175 nM for PKC_ε). Inhibits carbachol-evoked noradrenaline release (IC₅₀ = 600 nM).

Biochem/physiol Actions

Cell permeable: yes

RO-31-7549 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-31-7549 Suppliers

Canada 1 China 27 Japan 2 Switzerland 3 United Kingdom 2 United States 5 Global 40

J & K SCIENTIFIC LTD.

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Chemsky (shanghai) International Co.,Ltd

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Sigma-Aldrich

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Energy Chemical

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TargetMol Chemicals Inc.

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Hangzhou MolCore BioPharmatech Co.,Ltd.

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125313-65-7, RO-31-7549Related Search:

Bisindolylmaleimide V RO 31-7549, IMMOBILIZED RO 31-7549 ACETATE 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione 3-Isopropenyl-1-methyl-1H-pyrrole RO-31-7549

BISINDOLYLMALEIMIDE VIII ACETATE

1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-

3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Bisindolylmaleimide VIII

2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE

RO-31-7549

RO 31-7549 ACETATE SALT

BIDINDOLYLMALEIMIDE VIII, ACETETE

Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem

125313-65-7

C24H22N4O2C2H4O2

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators