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AC-DEVD-AMC

Product Name
AC-DEVD-AMC
CAS No.
169332-61-0
Chemical Name
AC-DEVD-AMC
Synonyms
Ac-Devd;AC-DEVD-AMC;AC-DMQD-AMC;AC-DEVD-MCA;ACETYL-DEVD-AMC;AC-DEVD-AMC USP/EP/BP;AC-ASP-MET-GLN-ASP-AMC;AC-ASP-GLU-VAL-ASP-MCA;AC-ASP-GLU-VAL-ASP-AMC;AC-DEVD-AMC AMMONIUM SALT
CBNumber
CB1285721
Molecular Formula
C30H37N5O13
Formula Weight
675.64
MOL File
169332-61-0.mol
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AC-DEVD-AMC Property

Boiling point:
1200.1±65.0 °C(Predicted)
Density 
1.423±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 10 mM
form 
powder
pka
4.09±0.10(Predicted)
color 
white
Sequence
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin
InChIKey
ALZSTTDFHZHSCA-RNVDEAKXSA-N
SMILES
C12C(C)=CC(=O)OC1=CC(NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)C)CC(=O)O)=CC=2 |&1:13,21,28,37,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
235425
Product name
Caspase-3 Substrate II, Fluorogenic
Purity
Fluorogenic caspase-3 substrate.
Packaging
1mg
Price
$114
Updated
2025/07/31
Sigma-Aldrich
Product number
235425
Product name
Caspase-3 Substrate II, Fluorogenic
Purity
Fluorogenic caspase-3 substrate.
Packaging
5mg
Price
$461
Updated
2025/07/31
Cayman Chemical
Product number
14986
Product name
Ac-DEVD-AMC
Purity
≥95%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
14986
Product name
Ac-DEVD-AMC
Purity
≥95%
Packaging
5mg
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
A1086
Product name
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
Purity
≥97% (HPLC), powder
Packaging
5mg
Price
$489
Updated
2025/07/31
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AC-DEVD-AMC Chemical Properties,Usage,Production

Description

Ac-DEVD-AMC is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.

Uses

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin has been used as a substrate for caspase-3 assay in human colon cancer cell line and in bone marrow mesenchymal stem cells.

Biochem/physiol Actions

Fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Excitation / Emission Maximum

340-360 nm/440-460 nm

Sequene

Ac-Asp-Glu-Val-Asp-AMC

AC-DEVD-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-DEVD-AMC Suppliers

China 140 France 1 Japan 3 Switzerland 2 United Kingdom 3 United States 16 Global 165
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74

169332-61-0, AC-DEVD-AMCRelated Search:

4-Methylcumarin N-acetyl aspartyl-glutaMic acid AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN AC-DEVD-AFC AC-DEVD-CHO AC-DEVD-AMC 4-(3-METHOXY-PHENYLAMINO)-BUTAN-1-OL 4-(3-METHOXYANILINO)-4-OXOBUTANOIC ACID CHEMBRDG-BB 5539774 CASPASE-3 SUBSTRATE AC-DEVD-AMC TFA SUC-ALA-ALA-ALA-AMC

  • AC-ASP-MET-GLN-ASP-AMC
  • AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN
  • AC-ASP-GLU-VAL-ASP-MCA
  • AC-ASP-GLU-VAL-ASP-7-AMINO-4-METHYLCOUMARIN
  • AC-ASP-GLU-VAL-ASP-AMC
  • AC-ASP-GLU-VAL-ASP-AMC AMMONIUM SALT
  • AC-DEVD-AMC
  • AC-DEVD-AMC AMMONIUM SALT
  • AC-DEVD-MCA
  • AC-DMQD-AMC
  • ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPARTIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)
  • ACETYL-DEVD-AMC
  • ACETYL-ASP-GLU-VAL-ASP-7-AMIDO-4-METHYLCOUMARIN
  • ACETYL-ASP-GLU-VAL-ASP-(AMINO-4-METHYLCOUMARIN)
  • CASPASE-3 FLUOROGENIC SUBSTRATE
  • CASPASE-3/CPP32 FLUOROGENIC SUBSTRATE
  • CASPASE 3 (APOPAIN) SUBSTRATE 1M, FLUOROGENIC
  • CASPASE 3 SUBSTRATE 1M, FLUOROGENIC
  • CASPASE-3 SUBSTRATE (FLUOROGENIC)
  • CASPASE-3 SUBSTRATE II, FLUOROGENIC
  • N-ACETYL-ASP-GLU-VAL-ASP-7-AMINO-4-METHYLCOUMARIN AMC
  • n-acetyl-asp-glu-val-asp-7-amido-4-methylcoumarin
  • Ac-Devd
  • AC-ASP-MET-GLN-ASP-AMC: AC-DMQD-AMC
  • Caspase 3 Substrate 1m (Apopain), fluorogenic: Ac-DEVD-AMC
  • APOPAIN SUBSTRATE ;AC-ASP-GLU-VAL-ASP-AMC
  • Caspase 3 Substrate 1m (Apopain), fluorogenic
  • Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem
  • L-α-Asparagine, N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin >=97% (HPLC), powder
  • AC-DEVD-AMC USP/EP/BP
  • Caspase 3 (Apopain) Substrate 1m, fluorogenic - 5 mg
  • 169332-61-0
  • 169322-61-0
  • C30H37N5O13
  • Apoptosis and Cell Cycle
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Caspase 3
  • Caspases
  • Substrates
  • Pepetides
  • peptide