Ethyl pyrazole-4-carboxylate

Product Name: Ethyl pyrazole-4-carboxylate
CAS No.: 37622-90-5
Chemical Name: Ethyl pyrazole-4-carboxylate
Synonyms: Ethyl 1H-pyrazole-4-carboxylate;ETHYL 4-PYRAZOLECARBOXYLATE;1H-Pyrazole-4-carboxylic acid ethyl ester;ecarboxyL;4-PyrazoL;Regadenoson impurity C;Regadenoson Impurity 7;4- pyrazoleethyl forMate;4-Ethoxycarbonylpyrazole;hylpyrazole-4-Carboxylate
CBNumber: CB1294747
Molecular Formula: C6H8N2O2
Formula Weight: 140.14
MOL File: 37622-90-5.mol

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Ethyl pyrazole-4-carboxylate Property

Melting point:: 78-80 °C (lit.)
Boiling point:: 138-140 °C/3 mmHg (lit.)
Density: 1.2850 (rough estimate)
refractive index: 1.5010 (estimate)
Flash point:: 138-140°C/3mm
storage temp.: Sealed in dry,Room Temperature
solubility: Miscible with acetone.
form: Crystalline Powder
pka: 11.70±0.50(Predicted)
color: White to pale yellow
InChI: InChI=1S/C6H8N2O2/c1-2-10-6(9)5-3-7-8-4-5/h3-4H,2H2,1H3,(H,7,8)
InChIKey: KACZQOKEFKFNDB-UHFFFAOYSA-N
SMILES: N1C=C(C(OCC)=O)C=N1
LogP: 0.909 (est)
CAS DataBase Reference: 37622-90-5(CAS DataBase Reference)
NIST Chemistry Reference: 4-(C2H5COO)-pyrazole(37622-90-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 300780
Product name: Ethyl 4-pyrazolecarboxylate
Purity: 99%
Packaging: 500mg
Price: $24
Updated: 2023/01/07

TCI Chemical

Product number: E0871
Product name: Ethyl 4-Pyrazolecarboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: E0871
Product name: Ethyl 4-Pyrazolecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $117
Updated: 2025/07/31

TRC

Product number: P842560
Product name: 4-PyrazolecarboxylicAcidEthylEster
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR13194
Product name: Ethyl1H-pyrazole-4-carboxylate
Purity: 98+%
Packaging: 100g
Price: $157
Updated: 2021/12/16

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Ethyl pyrazole-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow crystalline powder

Uses

Used for the synthesis of isoxazole-4-carboxylic acid derivatives and isoxazole-3,5-dicarboxamides as herbicides.

Uses

Ethyl pyrazole-4-carboxylate is used for the synthesis of isoxazole-4-carboxylic acid derivatives and isoxazole-3,5-dicarboxamides.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 30, p. 865, 1993 DOI: 10.1002/jhet.5570300404

Synthesis

80370-42-9

37622-90-5

The general procedure for the synthesis of ethyl 4-pyrazolecarboxylate from ethyl 2-formyl-3-oxopropanoate was as follows: 6.2 g (193 mmol) of hydrazine was slowly added to a solution of 27.6 g (192 mmol) of (ethoxycarbonyl)malondialdehyde dissolved in 150 mL of ethanol under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 17 hours to complete the reaction. Subsequently, ethanol was removed from the reaction mixture by vacuum distillation. The residue was purified by silica gel column chromatography using a solvent mixture of dichloromethane and ethyl acetate as the unfolding agent, resulting in 19.4 g (72.4% yield) of ethyl 1H-pyrazole-4-carboxylate as yellow crystals.1H-NMR [CDCl3/TMS, δ (ppm)]: 8.08 (2H, s), 5.30 (1H, s), 4.31 ( 2H, q), 1.36 (3H, t).

References

[1] Tetrahedron, 2008, vol. 64, # 33, p. 7745 - 7758
[2] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 4, p. 865 - 872
[3] Patent: EP1364946, 2003, A1. Location in patent: Page/Page column 196
[4] Patent: US2005/256004, 2005, A1. Location in patent: Page/Page column 32

Ethyl pyrazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl pyrazole-4-carboxylate manufacturers

Zibo Shiji Zhonglian Medical Technology Co., Ltd.

Product: Ethyl pyrazole-4-carboxylate 37622-90-5
Price: US $1.00/KG
Min. Order: 25KG
Purity: 99.0%
Supply Ability: 3000KG/th
Release date: 2023-06-16

Hebei Zhanyao Biotechnology Co. Ltd

Product: Ethyl 4-pyrazolecarboxylate 37622-90-5
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl pyrazole-4-carboxylate 37622-90-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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37622-90-5 Ethyl pyrazole-4-carboxylate

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