ChemicalBook > CAS DataBase List > Enalapril

Enalapril

Product Name
Enalapril
CAS No.
75847-73-3
Chemical Name
Enalapril
Synonyms
Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR
CBNumber
CB1295108
Molecular Formula
C20H28N2O5
Formula Weight
376.45
MOL File
75847-73-3.mol
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Enalapril Property

Melting point:
142-147℃
Boiling point:
582.4±50.0 °C(Predicted)
Density 
1.204±0.06 g/cm3(Predicted)
RTECS 
TW3665500
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
Powder
pka
pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
Water Solubility 
Soluble in water at 25mg/ml
BCS Class
3
CAS DataBase Reference
75847-73-3(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
Hazardous Substances Data
75847-73-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J60750
Product name
Enalapril
Packaging
1g
Price
$93.65
Updated
2024/03/01
Alfa Aesar
Product number
J60750
Product name
Enalapril
Packaging
5g
Price
$369.65
Updated
2024/03/01
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
5g
Price
$165
Updated
2021/12/16
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
1g
Price
$48
Updated
2021/12/16
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
10g
Price
$270
Updated
2021/12/16
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Enalapril Chemical Properties,Usage,Production

Uses

angiotensin converting enzyme inhibitor

Uses

It is used for hypertension and chronic cardiac insufficiency.

Uses

Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.

Definition

ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).

Mechanism of action

Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.

Synthesis

Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.

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Enalapril Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9442
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5877
Advantage
58
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View Lastest Price from Enalapril manufacturers

Hebei Lingding Biotechnology Co., Ltd.
Product
Enalapril 75847-73-3
Price
US $200.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-09-02
Zhuozhou Wenxi import and Export Co., Ltd
Product
Enalapril 75847-73-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Dideu Industries Group Limited
Product
Enalapril 75847-73-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-10

75847-73-3, EnalaprilRelated Search:


  • ENALAPRIL
  • (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline
  • 1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester
  • 1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2-CARBOXYLIC ACID
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
  • Renitec
  • Vasotec
  • Enalapril Maleate USP24
  • L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)-
  • L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-
  • (-)-1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • 1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH
  • N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH
  • (S)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)pyrrolidine-2-carboxylic acid
  • Enalapril AldrichCPR
  • (S)-1-[N-[1-(Ethoxyearbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • G1ioten
  • Hipoartd
  • (2S)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
  • (S)-N-[1-Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro
  • Enalapril hydrate
  • Enalapril USP/EP/BP
  • Enalaprilat dihydrat
  • EnalaprilQ: What is Enalapril Q: What is the CAS Number of Enalapril Q: What is the storage condition of Enalapril Q: What are the applications of Enalapril
  • Enalapril (MK-421)
  • ELAPRILAT DIHYDRAT
  • 75847-73-3
  • C20H28N2O5
  • Angiotensin