MK2-IN-1 (hydrochloride)

Product Name: MK2-IN-1 (hydrochloride)
CAS No.: 1314118-94-9
Chemical Name: MK2-IN-1 (hydrochloride)
Synonyms: MK 25;MK2 Inhibitor IV;MK 25 (hydrochloride);MK2-IN-1 (hydrochloride);MK2 inhibitor 1 hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride];inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2
CBNumber: CB13041430
Molecular Formula: C27H26Cl2N4O2
Formula Weight: 509.43
MOL File: 1314118-94-9.mol

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MK2-IN-1 (hydrochloride) Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in DMSO; ≥16.5 mg/mL in EtOH with ultrasonic; ≥37.4 mg/mL in H2O
form: A crystalline solid
color: Light yellow to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14399
Product name: MK2 Inhibitor IV
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 14399
Product name: MK2 Inhibitor IV
Purity: ≥95%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 14399
Product name: MK2 Inhibitor IV
Purity: ≥95%
Packaging: 25mg
Price: $356
Updated: 2024/03/01

ChemScene

Product number: CS-4584
Product name: MK2-IN-1hydrochloride
Purity: 99.19%
Packaging: 5mg
Price: $65
Updated: 2021/12/16

ApexBio Technology

Product number: C5545
Product name: MK2InhibitorIV
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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MK2-IN-1 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor with ic50 value of 0.11 μm [1].map kinase-activated protein kinase 2 (mapkapk2 or mk2) is a member of the ser/thr protein kinase family and regulated through direct phosphorylation by p38 map kinase. activation of the p38/mk2 pathway involved in promoting pro-inflammatory cytokine production and related inflammatory diseases [1].mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor. in a broad panel of 150 protein kinases, mk2 inhibitor iv only significantly inhibited ck1γ3 at greater than 50%. mk2 inhibitor iv also demonstrated no inhibition against a panel of cytochrome p450 (cyp) enzymes up to 30 μm. in the human thp1 acute monocytic leukemia cell line, mk2 inhibitor iv inhibited pro-inflammatory cytokine secretion. mk2 inhibitor iv also dose-dependently inhibited lps-stimulated tnfα and il6 secretion with ic50 values of 4.4 μm and 5.2 μm, respectively. in the sw1353 chondrosarcoma cell line and human primary chondrocyte cultures, mk2 inhibitor iv dose dependently inhibited il1β-stimulated matrixmetalloprotease (mmp)13 secretion with ic50 values of 5.7 μm and 2.2 μm, respectively.

References

[1]. huang x, shipps gw jr, cheng cc, et al. discovery and hit-to-lead optimization of non-atp competitive mk2 (mapkapk2) inhibitors. acs med chem lett. 2011 jun 24;2(8):632-7.

MK2-IN-1 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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MK2-IN-1 (hydrochloride) Suppliers

China 40 India 1 United States 9 Global 50

Haoyuan Chemexpress Co., Ltd.

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TargetMol Chemicals Inc.

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InvivoChem

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1314118-94-9, MK2-IN-1 (hydrochloride)Related Search:

MK2-IN-1 (hydrochloride)

MK2 Inhibitor IV

MK 25 (hydrochloride)

MK2 inhibitor 1 hydrochloride

MK 25

5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride]

5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride

inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2

1314118-94-9

C27H25ClN4O2HCl