TH287 (hydrochloride)

Product Name: TH287 (hydrochloride)
CAS No.: 1638211-05-8
Chemical Name: TH287 (hydrochloride)
Synonyms: CS-2086;TH287 HCl;TH287 hydrochloride, 10 mM in DMSO
CBNumber: CB13041470
Molecular Formula: C11H11Cl3N4
Formula Weight: 305.59
MOL File: 1638211-05-8.mol

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TH287 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31003098
Product name: TH287 hydrochloride
Purity: 98+%
Packaging: 5mg
Price: $52
Updated: 2021/12/16

Crysdot

Product number: CD31003098
Product name: TH287 hydrochloride
Purity: 98+%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

DC Chemicals

Product number: DC24091
Product name: TH287 hydrochloride
Purity: >98%
Packaging: 10mg
Price: $96
Updated: 2021/12/16

Crysdot

Product number: CD31003098
Product name: TH287 hydrochloride
Purity: 98+%
Packaging: 50mg
Price: $281
Updated: 2021/12/16

DC Chemicals

Product number: DC24091
Product name: TH287 hydrochloride
Purity: >98%
Packaging: 50mg
Price: $384
Updated: 2021/12/16

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TH287 (hydrochloride) Chemical Properties,Usage,Production

Description

TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.

References

[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

TH287 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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TH287 (hydrochloride) Suppliers

China 14 United States 4 Global 18

MedChemexpress LLC

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Shanghai EFE Biological Technology Co., Ltd.

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Amadis Chemical Company Limited

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Musechem

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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DC Chemicals

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Cckinase, Inc.

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Beijing xinyanhui pharmaceutical research and development co., LTD

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1638211-05-8, TH287 (hydrochloride)Related Search:

TH287 HCl

CS-2086

TH287 hydrochloride, 10 mM in DMSO

1638211-05-8