Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Product Name: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS No.: 1391728-01-0
Chemical Name: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Synonyms: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite;O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite;2-cyanoethyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) diisopropylphosphoramidite;Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester
CBNumber: CB13062620
Molecular Formula: C16H29N2O4P
Formula Weight: 344.39
MOL File: 1391728-01-0.mol

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Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Property

Boiling point:: 387.2±37.0 °C(Predicted)
pka: 3.53±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22317
Product name: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Purity: Tech
Packaging: 100mg
Price: $430
Updated: 2021/12/16

BroadPharm

Product number: BP-22317
Product name: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Purity: Tech
Packaging: 250mg
Price: $750
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1737
Product name: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Packaging: 100mg
Price: $837
Updated: 2021/12/16

BroadPharm

Product number: BP-22317
Product name: Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Purity: Tech
Packaging: 500mg
Price: $1125
Updated: 2021/12/16

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Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Properties,Usage,Production

Biological Activity

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Suppliers

China 12 United Kingdom 1 United States 2 Global 15

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1391728-01-0, Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramiditeRelated Search:

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O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester

2-cyanoethyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) diisopropylphosphoramidite

1391728-01-0

C16H29N2O4P