NG 012
- Product Name
- NG 012
- CAS No.
- 141731-76-2
- Chemical Name
- NG 012
- Synonyms
- NG 012;LL 15156α;LL 15G256α;NG 012 (NG 011);NG 012, CAS 141731-76-2;5H,9H,13H,21H,25H-Dibenzo[k,u][1,5,9,15,19]pentaoxacyclotetracosin-5,9,13,21,25-pentone, 7,8,11,12,15,16,23,24,27,28-decahydro-2,4,18,20-tetrahydroxy-11-(hydroxymethyl)-7,15,23,27-tetramethyl-, (7R,11S,15R,23R,27R)-
- CBNumber
- CB13136815
- Molecular Formula
- C32H38O15
- Formula Weight
- 662.64
- MOL File
- 141731-76-2.mol
NG 012 Property
- Boiling point:
- 1076.8±65.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- Pale white solid.
- pka
- 7.54±0.70(Predicted)
- color
- Pale white
N-Bromosuccinimide Price
- Product number
- 27509
- Product name
- NG 012
- Packaging
- 1mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 27509
- Product name
- NG 012
- Packaging
- 5mg
- Price
- $392
- Updated
- 2024/03/01
- Product number
- 27509
- Product name
- NG 012
- Packaging
- 500μg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- N393503
- Product name
- NG012
- Packaging
- 2.5mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 7429CZ
- Product name
- (4R,8R,18R,22S,26R)-12,14,30,32-Tetrahydroxy-22-(hydroxymethyl)-4,8,18,26-tetramethyl-3,7,17,21,25-pentaoxatricyclo[26.4.0.010,15]dotriaconta-1(28),10(15),11,13,29,31-hexaene-2,6,16,20,24-pentone
- Packaging
- 1mg
- Price
- $224
- Updated
- 2021/12/16
NG 012 Chemical Properties,Usage,Production
Description
NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties. It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro. NG 012 (50 μM) increases the efficacy of the antifungal miconazole against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.
Uses
NG 012 is a novel form of nerve growth factor potentiator.
storage
+4°C
References
[1] J BREINHOLT. Antifungal macrocyclic polylactones from Penicillium verruculosum.[J]. Journal of Antibiotics, 1993, 46 7: 1101-1108. DOI: 10.7164/antibiotics.46.1101
[2] M ITO. NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties.[J]. Journal of Antibiotics, 1992, 45 10: 1559-1565. DOI: 10.7164/antibiotics.45.1559
[3] MASAYOSHI ARAI. ChemInform Abstract: Funicone-Related Compounds, Potentiators of Antifungal Miconazole Activity, Produced by Talaromyces flavus FKI-0076.[J]. ChemInform, 2010, 33 33. DOI: 10.1002/chin.200233247
NG 012 Preparation Products And Raw materials
Raw materials
Preparation Products
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