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IN 1130

Product Name
IN 1130
CAS No.
868612-83-3
Chemical Name
IN 1130
Synonyms
IN 1130;IN1130,IN 1130;IN-1130, 10 mM in DMSO;3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide;3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide;Benzamide, 3-[[5-(6-methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-
CBNumber
CB13146308
Molecular Formula
C25H20N6O
Formula Weight
420.47
MOL File
868612-83-3.mol
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IN 1130 Property

Boiling point:
705.6±60.0 °C(Predicted)
Density 
1.315±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.60±0.10(Predicted)
form 
Solid
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1403
Product name
IN-1130
Purity
≥98% (HPLC)
Packaging
5MG
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1403
Product name
IN-1130
Purity
≥98% (HPLC)
Packaging
25MG
Price
$594
Updated
2025/07/31
Tocris
Product number
6016
Product name
IN1130
Purity
≥98%(HPLC)
Packaging
5
Price
$116
Updated
2021/12/16
TRC
Product number
I655855
Product name
IN1130
Packaging
2.5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0014265
Product name
IN-1130
Packaging
25mg
Price
$350
Updated
2021/12/16
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IN 1130 Chemical Properties,Usage,Production

Uses

IN 1130 is a novel transforming growth factor-?β type I receptor kinase (ALK5) inhibtior. In one study, it showed that IN-1130 was effective in prevention and treatment of renal fibrosis in rat unilateral ureteral obstruction model.

Biological Activity

IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC50 of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models.

in vivo

IN-1130 (10, 20 mg/kg/day; IP; for 7 and 14 days) reduces the extent of interstitial nephritis and fibrosis (arrowheads) with 10 mg/kg and significantly reduces or absent histopathological changes with 20 mg/kg in unilateral ureteral obstruction (UUO) rats[1].
? IN-1130 (10, 20 mg/kg/day; for 14 days) dose-dependently decreases levels of TGF-β1 mRNA and suppresses phosphorylation of Smad2, α-SMA, myofibroblasts in rat UUO kidneys[1].
? IN-1130 (40 mg/kg; IP; 3 times per week for 3 weeks) inhibits in vivo breast cancer metastasis to the lungs in MMTV/c-Neu mice (Eight-week-old female BALB/c mice)[2].

Animal Model:Six-week-old male Sprague–Dawley rats weighing 180-200 g[1]
Dosage:10 and 20 mg/kg
Administration:IP; daily; for 7 and 14 days
Result:Reduced the extent of interstitial nephritis and fibrosis (arrowheads) with 10 mg/kg.

IC 50

ALK5

storage

Store at +4°C

IN 1130 Preparation Products And Raw materials

Raw materials

Preparation Products

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IN 1130 Suppliers

China 26 United Kingdom 1 United States 3 Global 30
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1643
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62220
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58

868612-83-3, IN 1130Related Search:


  • IN 1130
  • 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide
  • IN1130,IN 1130
  • Benzamide, 3-[[5-(6-methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-
  • 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide
  • IN-1130, 10 mM in DMSO
  • 868612-83-3