IN 1130
- Product Name
- IN 1130
- CAS No.
- 868612-83-3
- Chemical Name
- IN 1130
- Synonyms
- IN 1130;IN1130,IN 1130;IN-1130, 10 mM in DMSO;3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide;3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide;Benzamide, 3-[[5-(6-methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-
- CBNumber
- CB13146308
- Molecular Formula
- C25H20N6O
- Formula Weight
- 420.47
- MOL File
- 868612-83-3.mol
IN 1130 Property
- Boiling point:
- 705.6±60.0 °C(Predicted)
- Density
- 1.315±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.60±0.10(Predicted)
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- SML1403
- Product name
- IN-1130
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $150
- Updated
- 2025/07/31
- Product number
- SML1403
- Product name
- IN-1130
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $594
- Updated
- 2025/07/31
- Product number
- 6016
- Product name
- IN1130
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $116
- Updated
- 2021/12/16
- Product number
- I655855
- Product name
- IN1130
- Packaging
- 2.5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0014265
- Product name
- IN-1130
- Packaging
- 25mg
- Price
- $350
- Updated
- 2021/12/16
IN 1130 Chemical Properties,Usage,Production
Uses
IN 1130 is a novel transforming growth factor-?β type I receptor kinase (ALK5) inhibtior. In one study, it showed that IN-1130 was effective in prevention and treatment of renal fibrosis in rat unilateral ureteral obstruction model.
Biological Activity
IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC50 of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models.
in vivo
IN-1130 (10, 20 mg/kg/day; IP; for 7 and 14 days) reduces the extent of interstitial nephritis and fibrosis (arrowheads) with 10 mg/kg and significantly reduces or absent histopathological changes with 20 mg/kg in unilateral ureteral obstruction (UUO) rats[1].
?
IN-1130 (10, 20 mg/kg/day; for 14 days) dose-dependently decreases levels of TGF-β1 mRNA and suppresses phosphorylation of Smad2, α-SMA, myofibroblasts in rat UUO kidneys[1].
?
IN-1130 (40 mg/kg; IP; 3 times per week for 3 weeks) inhibits in vivo breast cancer metastasis to the lungs in MMTV/c-Neu mice (Eight-week-old female BALB/c mice)[2].
| Animal Model: | Six-week-old male Sprague–Dawley rats weighing 180-200 g[1] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | IP; daily; for 7 and 14 days |
| Result: | Reduced the extent of interstitial nephritis and fibrosis (arrowheads) with 10 mg/kg. |
IC 50
ALK5
storage
Store at +4°C
IN 1130 Preparation Products And Raw materials
Raw materials
Preparation Products
IN 1130 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80