3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide

Product Name: 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
CAS No.: 863604-64-2
Chemical Name: 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Synonyms: 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide;Benzamide, 3-fluoro-N-methoxy-N-methyl-4-nitro-
CBNumber: CB13146919
Molecular Formula: C9H9FN2O4
Formula Weight: 228.18
MOL File: 863604-64-2.mol

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3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Property

Boiling point:: 411.0±35.0 °C(Predicted)
Density: 1.365±0.06 g/cm3(Predicted)
storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 7308DN
Product name: 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Packaging: 250mg
Price: $114
Updated: 2021/12/16

Crysdot

Product number: CD12022691
Product name: 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Purity: 97%
Packaging: 1g
Price: $297
Updated: 2021/12/16

Alichem

Product number: 863604642
Product name: 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Packaging: 1g
Price: $356.38
Updated: 2021/12/16

Crysdot

Product number: CD12022691
Product name: 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Purity: 97%
Packaging: 5g
Price: $891
Updated: 2021/12/16

Alichem

Product number: 863604642
Product name: 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Packaging: 5g
Price: $1058.76
Updated: 2021/12/16

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3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Chemical Properties,Usage,Production

Synthesis

403-21-4

6638-79-5

863604-64-2

General procedure for the synthesis of 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide from 3-fluoro-4-nitrobenzoic acid and N-methoxymethylamine hydrochloride: 3-fluoro-4-nitrobenzoic acid (100 g, 540 mmol), EDCI (155.3 g, 810 mmol), NMM (178 mL. 1.62 mol) and N-methoxymethylamine hydrochloride (79.0 g, 810 mmol). The reaction mixture was stirred at room temperature for 17 h under nitrogen protection. Upon completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid (1 L) and transferred to a separatory funnel to separate the organic phase. The organic phase was washed sequentially with 1N sodium hydroxide solution (2 x 500mL) and water (250mL). All aqueous layers were back-extracted with ethyl acetate (2 × 500 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 102.3 g (448 mmol, 83% yield) of a yellow solid product. The product was confirmed by NMR hydrogen spectroscopy (DMSO-d6): δ 8.22-8.18 (t, J=8.0 Hz, 1H), 7.79-7.76 (d, J=11.5 Hz, 1H), 7.60-7.58 (d, J=8.3 Hz, 1H), 3.56 (s, 3H), 3.28 (s, 3H); the mass spectrometry analysis showed that [M+H]+= 229.1; liquid chromatography-mass spectrometry analysis showed a retention time of 2.27 min.

References

[1] Patent: WO2005/121147, 2005, A1. Location in patent: Page/Page column 105; 106
[2] Patent: WO2005/80380, 2005, A1. Location in patent: Page/Page column 21;26
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 15, p. 4050 - 4054

3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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863604-64-2, 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamideRelated Search:

3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide

Benzamide, 3-fluoro-N-methoxy-N-methyl-4-nitro-

863604-64-2