3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Product Name
- 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- CAS No.
- 863604-64-2
- Chemical Name
- 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Synonyms
- 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide;Benzamide, 3-fluoro-N-methoxy-N-methyl-4-nitro-
- CBNumber
- CB13146919
- Molecular Formula
- C9H9FN2O4
- Formula Weight
- 228.18
- MOL File
- 863604-64-2.mol
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Property
- Boiling point:
- 411.0±35.0 °C(Predicted)
- Density
- 1.365±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7308DN
- Product name
- 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Packaging
- 250mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- CD12022691
- Product name
- 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
- Product number
- 863604642
- Product name
- 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Packaging
- 1g
- Price
- $356.38
- Updated
- 2021/12/16
- Product number
- CD12022691
- Product name
- 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Purity
- 97%
- Packaging
- 5g
- Price
- $891
- Updated
- 2021/12/16
- Product number
- 863604642
- Product name
- 3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
- Packaging
- 5g
- Price
- $1058.76
- Updated
- 2021/12/16
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Chemical Properties,Usage,Production
Synthesis
403-21-4
6638-79-5
863604-64-2
General procedure for the synthesis of 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide from 3-fluoro-4-nitrobenzoic acid and N-methoxymethylamine hydrochloride: 3-fluoro-4-nitrobenzoic acid (100 g, 540 mmol), EDCI (155.3 g, 810 mmol), NMM (178 mL. 1.62 mol) and N-methoxymethylamine hydrochloride (79.0 g, 810 mmol). The reaction mixture was stirred at room temperature for 17 h under nitrogen protection. Upon completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid (1 L) and transferred to a separatory funnel to separate the organic phase. The organic phase was washed sequentially with 1N sodium hydroxide solution (2 x 500mL) and water (250mL). All aqueous layers were back-extracted with ethyl acetate (2 × 500 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 102.3 g (448 mmol, 83% yield) of a yellow solid product. The product was confirmed by NMR hydrogen spectroscopy (DMSO-d6): δ 8.22-8.18 (t, J=8.0 Hz, 1H), 7.79-7.76 (d, J=11.5 Hz, 1H), 7.60-7.58 (d, J=8.3 Hz, 1H), 3.56 (s, 3H), 3.28 (s, 3H); the mass spectrometry analysis showed that [M+H]+= 229.1; liquid chromatography-mass spectrometry analysis showed a retention time of 2.27 min.
References
[1] Patent: WO2005/121147, 2005, A1. Location in patent: Page/Page column 105; 106
[2] Patent: WO2005/80380, 2005, A1. Location in patent: Page/Page column 21;26
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 15, p. 4050 - 4054
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Suppliers
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