bpV(phen) (potassium hydrate)
- Product Name
- bpV(phen) (potassium hydrate)
- CAS No.
- 171202-16-7
- Chemical Name
- bpV(phen) (potassium hydrate)
- Synonyms
- bpV(phen) trihydrate;bpV(phen) (potassium hydrate);Bisperoxovanadium (Bisperoxovanadium(phen)
- CBNumber
- CB13152565
- Molecular Formula
- C12H10KN2O6V
- Formula Weight
- 368.26
- MOL File
- 171202-16-7.mol
bpV(phen) (potassium hydrate) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- Yellow to orange
N-Bromosuccinimide Price
- Product number
- 13331
- Product name
- bpV(phen) (potassium hydrate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 13331
- Product name
- bpV(phen) (potassium hydrate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $185
- Updated
- 2024/03/01
- Product number
- B676685
- Product name
- bpV(phen)(PotassiumHydrate)
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- AG-CR1-0042-M005
- Product name
- bpV(phen)
- Purity
- ≥99%(51V-NMR)
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0089738
- Product name
- bpV(phen)trihydrate
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
bpV(phen) (potassium hydrate) Chemical Properties,Usage,Production
Description
bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-
Uses
bpV(phen) (Potassium Hydrate) inhibits several different protein tyrosine phosphatases (PTPs).
in vivo
BpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume[1].
| Animal Model: | Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 38 days |
| Result: | Caused a significant reduction in average tumor volume. |
IC 50
Leishmania
References
[1] J-P LAI D L K J T Dalton. Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair[J]. British Journal of Pharmacology, 2009, 152 8: 1172-1184. DOI: 10.1038/sj.bjp.0707501
[2] ANNETTE C. SCHMID. Bisperoxovanadium compounds are potent PTEN inhibitors[J]. FEBS Letters, 2004, 566 1-3: 35-38. DOI: 10.1016/j.febslet.2004.03.102
[3] AZUCENA KAKAZU H E P B Guru Sharma. Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing.[J]. Investigative ophthalmology & visual science, 2008: 2927-2935. DOI: 10.1167/iovs.07-0709
[4] IAN H BATTY. The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.[J]. Biochemical Journal, 2007, 407 2: 255-266. DOI: 10.1042/bj20070558
[5] B I POSNER. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.[J]. The Journal of Biological Chemistry, 1994, 269 6: 4596-4604.
[6] A P BEVAN. Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling.[J]. The Journal of Biological Chemistry, 1995, 270 18: 10784-10791. DOI: 10.1074/jbc.270.18.10784
[7] C J BAND. Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).[J]. Molecular endocrinology, 1997, 11 13: 1899-1910. DOI: 10.1210/mend.11.13.0041
bpV(phen) (potassium hydrate) Preparation Products And Raw materials
Raw materials
Preparation Products
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