bpV(phen) (potassium hydrate)

Product Name: bpV(phen) (potassium hydrate)
CAS No.: 171202-16-7
Chemical Name: bpV(phen) (potassium hydrate)
Synonyms: bpV(phen) trihydrate;bpV(phen) (potassium hydrate);Bisperoxovanadium (Bisperoxovanadium(phen)
CBNumber: CB13152565
Molecular Formula: C12H10KN2O6V
Formula Weight: 368.26
MOL File: 171202-16-7.mol

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bpV(phen) (potassium hydrate) Property

storage temp.: Store at -20°C
solubility: DMSO: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13331
Product name: bpV(phen) (potassium hydrate)
Purity: ≥98%
Packaging: 5mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 13331
Product name: bpV(phen) (potassium hydrate)
Purity: ≥98%
Packaging: 25mg
Price: $185
Updated: 2024/03/01

TRC

Product number: B676685
Product name: bpV(phen)(PotassiumHydrate)
Packaging: 10mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 1431EN
Product name: Potassium;oxovanadium;1,10-phenanthroline;diperoxide;trihydrate
Packaging: 5mg
Price: $187
Updated: 2021/12/16

ChemScene

Product number: CS-0089738
Product name: bpV(phen)trihydrate
Purity: ≥98.0%
Packaging: 25mg
Price: $195
Updated: 2021/12/16

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bpV(phen) (potassium hydrate) Chemical Properties,Usage,Production

Description

bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC₅₀ = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC₅₀ = 343 nM), and PTP-1β (IC₅₀ = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.

Uses

bpV(phen) (Potassium Hydrate) inhibits several different protein tyrosine phosphatases (PTPs).

in vivo

BpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume^[1].

Animal Model:	Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells^[2]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; daily; for 38 days
Result:	Caused a significant reduction in average tumor volume.

IC 50

Leishmania

References

[1] J-P LAI D L K J T Dalton. Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair[J]. British Journal of Pharmacology, 2009, 152 8: 1172-1184. DOI: 10.1038/sj.bjp.0707501
[2] ANNETTE C. SCHMID. Bisperoxovanadium compounds are potent PTEN inhibitors[J]. FEBS Letters, 2004, 566 1-3: 35-38. DOI: 10.1016/j.febslet.2004.03.102
[3] AZUCENA KAKAZU H E P B Guru Sharma. Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing.[J]. Investigative ophthalmology & visual science, 2008: 2927-2935. DOI: 10.1167/iovs.07-0709
[4] IAN H BATTY. The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.[J]. Biochemical Journal, 2007, 407 2: 255-266. DOI: 10.1042/bj20070558
[5] B I POSNER. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.[J]. The Journal of Biological Chemistry, 1994, 269 6: 4596-4604.
[6] A P BEVAN. Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling.[J]. The Journal of Biological Chemistry, 1995, 270 18: 10784-10791. DOI: 10.1074/jbc.270.18.10784
[7] C J BAND. Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).[J]. Molecular endocrinology, 1997, 11 13: 1899-1910. DOI: 10.1210/mend.11.13.0041

bpV(phen) (potassium hydrate) Preparation Products And Raw materials

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bpV(phen) (potassium hydrate) Suppliers

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bpV(phen) (potassium hydrate)

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bpV(phen) trihydrate

171202-16-7