ChemicalBook > CAS DataBase List > TAK-931

TAK-931

Product Name: TAK-931
CAS No.: 1330782-76-7
Chemical Name: TAK-931
Synonyms: TAK-931;ZL-2309;SIMUROSERTIB;TAK-931，Simurosertib;Simurosertib (TAK-931);Simurosertib, 10 mM in DMSO;(S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one;(S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(1H)-one;Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-;2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)-1H,4H-thieno[3,2-d]pyrimidin-4-one
CBNumber: CB13364621
Molecular Formula: C17H19N5OS
Formula Weight: 341.43
MOL File: 1330782-76-7.mol

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TAK-931 Property

storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
color: White to off-white
InChI: InChI=1S/C17H19N5OS/c1-9-11(8-18-21-9)14-7-12-15(24-14)17(23)20-16(19-12)13-6-10-2-4-22(13)5-3-10/h7-8,10,13H,2-6H2,1H3,(H,18,21)(H,19,20,23)/t13-/m0/s1
InChIKey: XGVXKJKTISMIOW-ZDUSSCGKSA-N
SMILES: C1([C@@H]2CC3CCN2CC3)NC(=O)C2SC(C3=CNN=C3C)=CC=2N=1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 2mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 5mg
Price: $230
Updated: 2021/12/16

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 10mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC21653
Product name: Simurosertib(TAK-931)
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

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TAK-931 Chemical Properties,Usage,Production

Uses

Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity[1].

in vivo

In the COLO205-xenograft mouse model, oral administration of Simurosertib (TAK-931) inhibits pMCM2 of the xenografted COLO205 in dose- and time-dependent manners. Furthermore, Simurosertib (TAK-931) exhibits a significant antitumor activity in multiple xenograft models^[1].

IC 50

Cdc7: <0.3 nM (IC₅₀)

References

[1] K Iwai, et al. A novel CDC7-selective inhibitor TAK-931 with potent antitumor activity. European Journal of Cancer , 2016 , 69 (1) :S34.

TAK-931 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAK-931 Suppliers

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1330782-76-7, TAK-931Related Search:

2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1~{H}-pyrazol-4-yl)-3~{H}-thieno[3,2-d]pyrimidin-4-one

SIMUROSERTIB

TAK-931

(S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one

Simurosertib (TAK-931)

Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-

TAK-931，Simurosertib

Inhibitor,anti-cancer,Cyclin dependent kinase,ATP-competitive,CDK,TAK931,Simurosertib,cycle,cell,orally,inhibit,division,TAK 931

2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)-1H,4H-thieno[3,2-d]pyrimidin-4-one

(S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(1H)-one

Simurosertib, 10 mM in DMSO

ZL-2309

1330782-76-7