Tucidinostat (Chidamide)

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Tucidinostat (Chidamide)

Product Name: Tucidinostat (Chidamide)
CAS No.: 1616493-44-7
Chemical Name: Tucidinostat (Chidamide)
Synonyms: CS055;TUCIDINOSTAT;Cidabenzamine;CS055; HBI-8000;HBI-8000， CS-055;Chidamide (Tucidinostat, HBI8000, CS 055);Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza;HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit;N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide;Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-
CBNumber: CB13389703
Molecular Formula: C22H19FN4O2
Formula Weight: 390.41
MOL File: 1616493-44-7.mol

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Tucidinostat (Chidamide) Property

Boiling point:: 602.1±55.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 12.05±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 25mg
Price: $266
Updated: 2024/03/01

TRC

Product number: C291980
Product name: Chidamide
Packaging: 250mg
Price: $1320
Updated: 2021/12/16

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Tucidinostat (Chidamide) Chemical Properties,Usage,Production

Description

Chidamide is an inhibitor of histone deacetylases (HDACs; IC₅₀s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 μM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC₅₀s = >30 μM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC₅₀ = 2.1 μM). It inhibits cell growth in a panel of 18 cancer cell lines (GI₅₀s = 0.4-40 μM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI₅₀s = >100 μM). In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.

Uses

Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.

Definition

ChEBI: Chidamide is a member of benzamides.

Tucidinostat (Chidamide) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tucidinostat (Chidamide) manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Tucidinostat (Chidamide) 1616493-44-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Career Henan Chemical Co

Product: Tucidinostat (Chidamide) 1616493-44-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

1616493-44-7, Tucidinostat (Chidamide)Related Search:

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TUCIDINOSTAT

N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide

Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza

CS055

CS055; HBI-8000

Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-

HBI-8000， CS-055

Chidamide (Tucidinostat, HBI8000, CS 055)

HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit

Cidabenzamine

1616493-44-7