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Tucidinostat (Chidamide)

Product Name
Tucidinostat (Chidamide)
CAS No.
1616493-44-7
Chemical Name
Tucidinostat (Chidamide)
Synonyms
CS055;TUCIDINOSTAT;Cidabenzamine;CS055; HBI-8000;HBI-8000， CS-055;Chidamide (Tucidinostat, HBI8000, CS 055);Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza;HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit;N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide;Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-
CBNumber
CB13389703
Molecular Formula
C22H19FN4O2
Formula Weight
390.41
MOL File
1616493-44-7.mol
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Tucidinostat (Chidamide) Property

Boiling point:
602.1±55.0 °C(Predicted)
Density 
1.336±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
12.05±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13686
Product name
Chidamide
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
13686
Product name
Chidamide
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
13686
Product name
Chidamide
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
13686
Product name
Chidamide
Packaging
25mg
Price
$266
Updated
2024/03/01
TRC
Product number
C291980
Product name
Chidamide
Packaging
250mg
Price
$1320
Updated
2021/12/16
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Tucidinostat (Chidamide) Chemical Properties,Usage,Production

Description

Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 μM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 μM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 μM). It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 μM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 μM). In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.

Uses

Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.

Definition

ChEBI: Chidamide is a member of benzamides.

Tucidinostat (Chidamide) Preparation Products And Raw materials

Raw materials

Preparation Products

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Tucidinostat (Chidamide) Suppliers

China 65 India 1 United States 8 Global 74
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
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58
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View Lastest Price from Tucidinostat (Chidamide) manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Tucidinostat (Chidamide) 1616493-44-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Career Henan Chemical Co
Product
Tucidinostat (Chidamide) 1616493-44-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98-100%
Supply Ability
1000kg
Release date
2018-08-20

1616493-44-7, Tucidinostat (Chidamide)Related Search:

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  • TUCIDINOSTAT
  • N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide
  • Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza
  • CS055
  • CS055; HBI-8000
  • Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-
  • HBI-8000， CS-055
  • Chidamide (Tucidinostat, HBI8000, CS 055)
  • HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit
  • Cidabenzamine
  • 1616493-44-7