L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
- Product Name
- L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
- CAS No.
- 42438-90-4
- Chemical Name
- L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
- Synonyms
- TCR;TNCA;L -CarL;H-TPI-OH;H-THNH(3)-OH;Lycoperodine 1;TNCA >=98% (HPLC);RARECHEM BK PT 0088;CYCLOMETHYLTRYPTOPHAN;Tryptophan Impurity M
- CBNumber
- CB1395455
- Molecular Formula
- C12H12N2O2
- Formula Weight
- 216.24
- MOL File
- 42438-90-4.mol
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Property
- Melting point:
- 289 °C (dec.)(lit.)
- Boiling point:
- 485.0±45.0 °C(Predicted)
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
- pka
- 2.28±0.20(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
- InChIKey
- FSNCEEGOMTYXKY-JTQLQIEISA-N
- CAS DataBase Reference
- 42438-90-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1711
- Product name
- (S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $58.5
- Updated
- 2025/07/31
- Product number
- SML1711
- Product name
- (S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $240
- Updated
- 2025/07/31
- Product number
- T4198
- Product name
- H-Tpi-OH
- Packaging
- 200MG
- Price
- $83
- Updated
- 2025/07/31
- Product number
- T4198
- Product name
- H-Tpi-OH
- Packaging
- 1G
- Price
- $249
- Updated
- 2025/07/31
- Product number
- T795458
- Product name
- L-1,2,3,4-Tetrahydronorharman-3-carboxylicAcid
- Packaging
- 200mg
- Price
- $160
- Updated
- 2021/12/16
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR)[1].
Biochem/physiol Actions
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.
References
[1] Shoji Yahara, et al. Steroidal Alkaloid Glycosides from Tomato (Lycopersicon esculentum). J Nat Prod. 2004 Mar;67(3):500-2. DOI:10.1021/np030382x
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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