1-(2-Chloroethyl)piperidine hydrochloride

Product Name: 1-(2-Chloroethyl)piperidine hydrochloride
CAS No.: 2008-75-5
Chemical Name: 1-(2-Chloroethyl)piperidine hydrochloride
Synonyms: N-(2-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE;PIPEC;1-(2-Chloroethyl)pip;Pramoxine Impurity 12;2-Piperidinoethyl chiloride;2-CHLOROETHYLPIPERIDINE HCL;PIPERIDINO ETHYL CHLORIDE HCL;2-ChloroethylpiperidineHcl98%;Levocloperastine CEP Impurity;N-(2-CHLOROETHYL)PIPERIDINE HCL
CBNumber: CB1412444
Molecular Formula: C7H15Cl2N
Formula Weight: 184.11
MOL File: 2008-75-5.mol

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1-(2-Chloroethyl)piperidine hydrochloride Property

Melting point:: 230-232 °C(lit.)
Boiling point:: 196 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Powder or Crystals
color: White to pale yellow to beige
Water Solubility: soluble
Sensitive: Hygroscopic
BRN: 3910268
InChI: InChI=1S/C7H14ClN.ClH/c8-4-7-9-5-2-1-3-6-9;/h1-7H2;1H
InChIKey: VFLQQZCRHPIGJU-UHFFFAOYSA-N
SMILES: N1(CCCl)CCCCC1.Cl
CAS DataBase Reference: 2008-75-5(CAS DataBase Reference)

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Safety

Hazard Codes: T+,Xi
Risk Statements: 28-34-36/37/38
Safety Statements: 26-28-36/37/39-45-24/25
RIDADR: UN 2928 6.1/PG 2
WGK Germany: 2
RTECS: TM6482500
HazardClass: 6.1
PackingGroup: II
HS Code: 29333999
Toxicity: mouse,LD50,intraperitoneal,93mg/kg (93mg/kg),BEHAVIORAL: ATAXIA,Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C42602
Product name: 1-(2-Chloroethyl)piperidine hydrochloride
Purity: 98%
Packaging: 100g
Price: $72.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: C42602
Product name: 1-(2-Chloroethyl)piperidine hydrochloride
Purity: 98%
Packaging: 500g
Price: $203
Updated: 2022/05/15

TCI Chemical

Product number: C1073
Product name: 1-(2-Chloroethyl)piperidine Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: C1073
Product name: 1-(2-Chloroethyl)piperidine Hydrochloride
Purity: >98.0%(T)
Packaging: 500g
Price: $457
Updated: 2025/07/31

TRC

Product number: C366745
Product name: N-(β-Chloroethyl)piperidineHydrochloride
Packaging: 100g
Price: $165
Updated: 2021/12/16

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1-(2-Chloroethyl)piperidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to beige crystals

Uses

Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.

Uses

1-(2-Chloroethyl)piperidine hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. fenpiverinium bromide, cloperastine and pitofenone).

Synthesis

3040-44-6

2008-75-5

The general procedure for the synthesis of 1-(2-chloroethyl)piperidine hydrochloride using N-hydroxyethylpiperidine as starting material was as follows: N-hydroxyethylpiperidine (5 mL) was dissolved in chloroform (12.5 mL). Thionyl chloride (3.4 mL) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was slowly heated to reflux and the reflux reaction was maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give a large crystalline precipitate. Finally, the product was purified by ethanol recrystallization to give 5.88 g of 1-(2-chloroethyl)piperidine hydrochloride in 85% yield.

References

[1] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0048; 0049
[2] Patent: US2006/223855, 2006, A1. Location in patent: Page/Page column 160-161
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679

1-(2-Chloroethyl)piperidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Chloroethyl)piperidine hydrochloride Suppliers

Americas 1 Belgium 1 China 224 Europe 3 France 2 Germany 5 India 20 Japan 3 Slovakia 1 South Korea 3 Switzerland 4 The Netherlands 1 United Kingdom 18 United States 46 Global 332

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View Lastest Price from 1-(2-Chloroethyl)piperidine hydrochloride manufacturers

Career Henan Chemical Co

Product: 2-Piperidinoethylchloride hydrochloride 2008-75-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-21

2008-75-5, 1-(2-Chloroethyl)piperidine hydrochlorideRelated Search:

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2008-75-5 2-Piperidinoethylchloride hydrochloride

1-(2-Chloroethyl)piperidine hydrochloride - [C13526]

Pramoxine Impurity 12

2008-75-5

2008-78-5

C7H14ClNxHCl

C7H14ClNHCl

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Piperidines

Piperidines, Piperidones, Piperazines

Piperidine