HUMAN IGFBP-3
Description Source Background- Product Name
- HUMAN IGFBP-3
- Chemical Name
- HUMAN IGFBP-3
- Synonyms
- IBP3;IBP-3;IGFBP-3;HUMAN IGFBP-3;IGFBP-3, HUMAN;IGF BINDING PROTEIN-3;IGF-Binding Protein-3 human;IGF Binding Protein-3, IGFBP-3;Growth-hormone-dependant binding protein;Recombinant Human IGFBP3 Protein, His Tag
- CBNumber
- CB1432006
- Formula Weight
- 0
- MOL File
- Mol file
HUMAN IGFBP-3 Property
- storage temp.
- −20°C
- form
- lyophilized powder
- color
- white to off-white
- biological source
- human
Safety
- Hazard Codes
- T,C,F
- Risk Statements
- 23/24/25-36/37/38-52/53-35-20/21/22-11
- Safety Statements
- 26-36/37/39-45-61
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- I5278
- Product name
- Insulin-Like Growth Factor Binding Protein-3 human
- Purity
- recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
- Packaging
- 25 μg
- Price
- $657.59
- Updated
- 2025/07/31
- Product number
- I7661-16L3-AP
- Product name
- Insulin-like Growth Factor Binding Protein 3
- Packaging
- 200ul
- Price
- $711
- Updated
- 2021/12/16
- Product number
- 152714
- Product name
- Insulin Like Growth Factor Binding Protein 3
- Packaging
- 96Tests
- Price
- $907
- Updated
- 2021/12/16
- Product number
- 155195
- Product name
- Insulin Like Growth Factor Binding Protein 3
- Packaging
- 10ug
- Price
- $343
- Updated
- 2021/12/16
- Product number
- 155196
- Product name
- Insulin Like Growth Factor Binding Protein 3
- Packaging
- 10ug
- Price
- $345
- Updated
- 2021/12/16
HUMAN IGFBP-3 Chemical Properties,Usage,Production
Uses
IGF-Binding Protein-3 human has been used to study its association with follicular fluid and subsequent effect on embryo development.
Biological Activity
IGFBP3 (insulin-like growth factor-binding protein 3) is involved in cell survival as well as cell death and tumorigenesis. Epigenetic changes in IGFBP3 affect non-small-cell lung cancer, hepatocellular carcinoma, ovarian cancer, skin cancer, urological cancers, breast cancer and gastric cancer. IGFBP3 is a primary growth inhibitor and can reverse the mitogenic functions of IGF-1 (insulin like growth factor 1) by inducing apoptosis.IGFBP-3 functions both in an IGF-dependent and independent manner. Its IGF-dependent roles involve endocrine function by delivering IGFs to target cells and activating downstream signaling. Meanwhile, its IGF-independent roles include interactions with extracellular matrix and plasma membrane proteins, as well as translocation into the cytoplasm and nucleus. The C-terminal domain has cell-penetrating abilities, enabling the generation of short peptides for intracellular delivery of drugs or genes.
Description
IGFBP3 Human Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing 264 amino acids and having a molecular mass of 28806 Dalton.
IGFBP-3 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
IGFBP3 is a member of the IGFBP family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with IGFALS and either IGF I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
HUMAN IGFBP-3 Preparation Products And Raw materials
Raw materials
Preparation Products
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