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SB 225002

Product Name
SB 225002
CAS No.
182498-32-4
Chemical Name
SB 225002
Synonyms
SB 225002;SB225002 ，S7651;CAS:182498-32-4;SB-225002;SB 225002;SB 225002 USP/EP/BP;SB225002 182498-32-4;SB225002, 10 mM in DMSO;SB 225002, non-peptide CXCR2 antagonist;SB 225002 - CAS 182498-32-4 - Calbiochem;1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
CBNumber
CB1455331
Molecular Formula
C13H10BrN3O4
Formula Weight
352.14
MOL File
182498-32-4.mol
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SB 225002 Property

Boiling point:
401.6±45.0 °C(Predicted)
Density 
1.793±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
Soluble to 100mM in DMSO and to 50mM in ethanol
form 
Yellow solid
pka
5.29±0.10(Predicted)
color 
white to beige
Sensitive 
Moisture Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
MQBZVUNNWUIPMK-UHFFFAOYSA-N
CAS DataBase Reference
182498-32-4
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0716
Product name
SB 225002
Purity
≥98% (HPLC)
Packaging
5mg
Price
$128
Updated
2025/07/31
Sigma-Aldrich
Product number
559405
Product name
SB 225002
Packaging
1mg
Price
$98.6
Updated
2025/07/31
TCI Chemical
Product number
B6055
Product name
SB 225002
Packaging
10MG
Price
$147
Updated
2025/07/31
TCI Chemical
Product number
B6055
Product name
SB 225002
Packaging
50MG
Price
$487
Updated
2025/07/31
Cayman Chemical
Product number
13336
Product name
SB 225002
Purity
≥95%
Packaging
5mg
Price
$82
Updated
2024/03/01
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SB 225002 Chemical Properties,Usage,Production

Description

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.

Uses

SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.

Definition

ChEBI: 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea is a nitrophenol.

Biological Activity

Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.

Biochem/physiol Actions

SB-225002 is a potent nonpeptide inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2 and > 150-fold selectivity over CXCR1 receptors. CXCR2 binds many different immune cell chemoattractants. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.

storage

Store at RT

References

[1] J R WHITE. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.[J]. The Journal of Biological Chemistry, 1998, 273 17: 10095-10098. DOI:10.1074/jbc.273.17.10095
[2] MEIRONG DU. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro.[J]. PLoS ONE, 2013: e54572. DOI:10.1371/journal.pone.0054572
[3] XIAO-HUA SHEN . Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation[J]. International immunopharmacology, 2013, 16 2: Pages 261-267. DOI:10.1016/j.intimp.2013.04.003
[4] B. LANE. Interleukin-8 Stimulates Human Immunodeficiency Virus Type 1 Replication and Is a Potential New Target for Antiretroviral Therapy[J]. Journal of Virology, 2001, 75 1: 8195-8202. DOI:10.1128/jvi.75.17.8195-8202.2001
[5] FENGJIAO WU. CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation.[J]. Journal of Neuroinflammation, 2015: 98. DOI:10.1186/s12974-015-0316-6

SB 225002 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 225002 Suppliers

Americas 1 China 137 Europe 1 India 2 Japan 2 United Kingdom 3 United States 17 Global 163
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
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58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
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55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
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7552
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61

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  • SB 225002
  • N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA
  • N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA
  • 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
  • SB 225002 - CAS 182498-32-4 - Calbiochem
  • SB-225002;SB 225002
  • Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-
  • SB 225002 USP/EP/BP
  • SB225002 182498-32-4
  • SB 225002, non-peptide CXCR2 antagonist
  • SB225002, 10 mM in DMSO
  • SB225002 ，S7651
  • CAS:182498-32-4
  • 182498-32-4
  • 18298-32-4
  • Inhibitors
  • A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2.
  • Antineoplastic