JH-VIII-157-02

Product Name: JH-VIII-157-02
CAS No.: 1639422-97-1
Chemical Name: JH-VIII-157-02
Synonyms: JH-VIII-157-02;JH-VIII-157-02, 10 mM in DMSO;1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-;CD246,Cluster of differentiation 246,inhibit,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK),ALK tyrosine kinase receptor,Inhibitor,JHVIII15702,JH VIII 157 02
CBNumber: CB14668070
Molecular Formula: C28H27N5O2
Formula Weight: 465.55
MOL File: 1639422-97-1.mol

More

Less

JH-VIII-157-02 Property

Boiling point:: 751.9±60.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 25 mg/mL (53.70 mM)
pka: 13.70±0.40(Predicted)
form: Solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0043469
Product name: JH-VIII-157-02
Purity: 98.86%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0043469
Product name: JH-VIII-157-02
Purity: 98.86%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0043469
Product name: JH-VIII-157-02
Purity: 98.86%
Packaging: 25mg
Price: $1600
Updated: 2021/12/16

ChemScene

Product number: CS-0043469
Product name: JH-VIII-157-02
Purity: 98.86%
Packaging: 50mg
Price: $2600
Updated: 2021/12/16

ChemScene

Product number: CS-0043469
Product name: JH-VIII-157-02
Purity: 98.86%
Packaging: 100mg
Price: $4500
Updated: 2021/12/16

More

Less

JH-VIII-157-02 Chemical Properties,Usage,Production

Biological Activity

JH-VIII-157-02, a structural analog of alectinib, is an ALK inhibitor with IC50 of 2 nM for echinoderms microtubule-associated protein-like 4 (EML4)-ALK G1202R.

in vivo

JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice.

target

IC50: 2 nM (EML4-ALK G1202R, cell assay), 2 nM (EML4-ALK ^wt , cell assay), 2 nM (EML4-ALK C1156Y, cell assay) , 2 nM (EML4-ALK F1174L, cell assay), 2 nM (EML4-ALK F1174L, cell assay)

JH-VIII-157-02 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

JH-VIII-157-02 Suppliers

China 22 United States 3 Global 25

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7323
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Shanghai Star Pharmaceutical Chemical Technology Co., Ltd.

Tel: 021-58521787 17701827760
Email: starpharmsh@gmail.com
Country: China
ProdList: 208
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shenyang Maud Pharmaceutical Technology Co., Ltd.

Tel: 024-23982345
Email: 1020788318@qq.com
Country: China
ProdList: 2251
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18478
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564
Email: August@easycdmo.com
Country: China
ProdList: 10030
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 14760821013 13564957716
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29979
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 4997
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

jiayishangmao

Tel: 18841420488
Email: 3775563470@qq.com
Country: China
ProdList: 77
Advantage: 58

Tel: 400-821-026
Email: sangon@qq.com
Country: China
ProdList: 47240
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32965
Advantage: 60

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6743
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

1639422-97-1, JH-VIII-157-02Related Search:

JH-VIII-157-02

1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-

CD246,Cluster of differentiation 246,inhibit,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK),ALK tyrosine kinase receptor,Inhibitor,JHVIII15702,JH VIII 157 02

JH-VIII-157-02, 10 mM in DMSO

1639422-97-1