JH-VIII-157-02
- Product Name
- JH-VIII-157-02
- CAS No.
- 1639422-97-1
- Chemical Name
- JH-VIII-157-02
- Synonyms
- JH-VIII-157-02;JH-VIII-157-02, 10 mM in DMSO;1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-;CD246,Cluster of differentiation 246,inhibit,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK),ALK tyrosine kinase receptor,Inhibitor,JHVIII15702,JH VIII 157 02
- CBNumber
- CB14668070
- Molecular Formula
- C28H27N5O2
- Formula Weight
- 465.55
- MOL File
- 1639422-97-1.mol
JH-VIII-157-02 Property
- Boiling point:
- 751.9±60.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 25 mg/mL (53.70 mM)
- pka
- 13.70±0.40(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0043469
- Product name
- JH-VIII-157-02
- Purity
- 98.86%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0043469
- Product name
- JH-VIII-157-02
- Purity
- 98.86%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0043469
- Product name
- JH-VIII-157-02
- Purity
- 98.86%
- Packaging
- 25mg
- Price
- $1600
- Updated
- 2021/12/16
- Product number
- CS-0043469
- Product name
- JH-VIII-157-02
- Purity
- 98.86%
- Packaging
- 50mg
- Price
- $2600
- Updated
- 2021/12/16
- Product number
- CS-0043469
- Product name
- JH-VIII-157-02
- Purity
- 98.86%
- Packaging
- 100mg
- Price
- $4500
- Updated
- 2021/12/16
JH-VIII-157-02 Chemical Properties,Usage,Production
Biological Activity
JH-VIII-157-02, a structural analog of alectinib, is an ALK inhibitor with IC50 of 2 nM for echinoderms microtubule-associated protein-like 4 (EML4)-ALK G1202R.
in vivo
JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice.
target
IC50: 2 nM (EML4-ALK G1202R, cell assay), 2 nM (EML4-ALK wt , cell assay), 2 nM (EML4-ALK C1156Y, cell assay) , 2 nM (EML4-ALK F1174L, cell assay), 2 nM (EML4-ALK F1174L, cell assay)
JH-VIII-157-02 Preparation Products And Raw materials
Raw materials
Preparation Products
JH-VIII-157-02 Suppliers
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- +1-781-999-5354 +1-00000000000
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- United States
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