ALX 40-4C

Product Name: ALX 40-4C
CAS No.: 143413-49-4
Chemical Name: ALX 40-4C
Synonyms: ALX 40-4C;D-Argininamide, N2-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl- (9CI)
CBNumber: CB14713635
Molecular Formula: C56H113N37O10
Formula Weight: 1464.74
MOL File: 143413-49-4.mol

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ALX 40-4C Property

Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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ALX 40-4C Chemical Properties,Usage,Production

Uses

ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.

IC 50

SDF-1-CXCR4: 1 μM (Ki); APJ receptor: 2.9 μM (IC₅₀)

References

[1] Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86. DOI:10.1089/08892220151126508
[2] Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. DOI:10.1016/s0166-3542(03)00071-8
[3] Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. DOI:10.1016/s0042-6822(03)00185-5

ALX 40-4C Preparation Products And Raw materials

Raw materials

Preparation Products

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ALX 40-4C Suppliers

China 30 United States 4 Global 34

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143413-49-4, ALX 40-4CRelated Search:

ALX 40-4C

D-Argininamide, N2-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl- (9CI)

143413-49-4

C56H113N37O10