N-(9,10-dioxo-9,10-dihydroanthracen-2-yl)benzamide

N-(9,10-dioxo-9,10-dihydroanthracen-2-yl)benzamide Property

storage temp. 

4°C, protect from light

form 

Solid

color 

Light brown to brown

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

N-(9,10-dioxo-9,10-dihydroanthracen-2-yl)benzamide Chemical Properties,Usage,Production

Description

SSAA09E3 is a novel inhibitor of SARS-CoV replication, acting by preventing fusion of the viral membrane with the host cellular membrane.

Uses

SSAA09E3 is a SARS-CoV entry inhibitor that inhibits SARS/HIV pseudotyped virus entry with an EC50 of 9.7 μM in 293T cells and inhibits SARS-CoV infection of Vero cells with an EC50 of 0.15 μM[1][2].

References

[1] Ghosh AK, et al. Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics. ChemMedChem. 2020 Jun 4;15(11):907-932. DOI:10.1002/cmdc.202000223
[2] Adedeji AO, et al. Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. J Virol. 2013 Jul;87(14):8017-28. DOI:10.1128/JVI.00998-13