KW-8232 free base

Product Name: KW-8232 free base
CAS No.: 170365-25-0
Chemical Name: KW-8232 free base
Synonyms: KW-8232 free base;KW8232 free base,KW 8232 free base;Methanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]-
CBNumber: CB14796665
Molecular Formula: C36H37ClN4O3
Formula Weight: 609.16
MOL File: 170365-25-0.mol

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KW-8232 free base Property

Boiling point:: 805.5±65.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 9.95±0.10(Predicted)
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0018456
Product name: KW-8232freebase
Packaging: 1mg
Price: $1450
Updated: 2021/12/16

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KW-8232 free base Chemical Properties,Usage,Production

Uses

KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].

in vivo

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production^[1].

Animal Model:	male Sprague-Dawley rats (5-week-old)^[1].
Dosage:	1, 3, 10, and 30 mg/kg.
Administration:	Orally once daily beginning 1 day prior to neurectomy for 28 days.
Result:	Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.

IC 50

EP

References

[1] Uchii M, et al. Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats. Jpn J Pharmacol. 1998 Oct;78(2):241-3. DOI:10.1254/jjp.78.241
[2] Shiwei Wang, et al. A Transferable Deep Learning Approach to Fast Screen Potent Antiviral Drugs against SARS-CoV-2. bioRxiv. 2020.

KW-8232 free base Preparation Products And Raw materials

Raw materials

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KW-8232 free base Suppliers

China 6 United States 5 Global 11

Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Guangzhou Xinghe Biotechnology Co., Ltd.

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170365-25-0, KW-8232 free baseRelated Search:

KW-8232 free base

Methanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]-

KW8232 free base,KW 8232 free base

170365-25-0

C36H37ClN4O3