DS 7423)

Product Name: DS 7423)
CAS No.: 1222104-37-1
Chemical Name: DS 7423)
Synonyms: DS 7423);DS-7423 (DS7423;DS-7423, 10 mM in DMSO;5-{8-[(3R)-4-Acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine;(R)-1-(4-(2-(2-Aminopyrimidin-5-yl)-6-morpholino-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl)-2-methylpiperazin-1-yl)ethan-1-one;Ethanone, 1-[(2R)-4-[2-(2-amino-5-pyrimidinyl)-6-(4-morpholinyl)-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]-2-methyl-1-piperazinyl]-;1-[(2R)-4-[2-(2-aminopyrimidin-5-yl)-6-(morpholin-4-yl)-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]-2-methylpiperazin-1-yl]ethan-1-one;DS7423,mTOR,Phosphoinositide 3-kinase,Inhibitor,DS-7423,inhibit,PUMA,TP53,Mammalian target of Rapamycin,PI3K,OCCC,TP53AIP1,DS 7423
CBNumber: CB14844731
Molecular Formula: C22H27F3N10O2
Formula Weight: 520.51
MOL File: 1222104-37-1.mol

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DS 7423) Property

Boiling point:: 665.3±65.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 3.93±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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DS 7423) Chemical Properties,Usage,Production

Uses

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].

Biological Activity

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2].

References

[1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42(7):757-62. [2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220.

DS 7423) Preparation Products And Raw materials

Raw materials

Preparation Products

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DS 7423) Suppliers

China 28 United States 3 Global 31

Finetech Industry Limited

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1222104-37-1, DS 7423)Related Search:

DS 7423)

DS-7423 (DS7423

DS7423,mTOR,Phosphoinositide 3-kinase,Inhibitor,DS-7423,inhibit,PUMA,TP53,Mammalian target of Rapamycin,PI3K,OCCC,TP53AIP1,DS 7423

5-{8-[(3R)-4-Acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine

Ethanone, 1-[(2R)-4-[2-(2-amino-5-pyrimidinyl)-6-(4-morpholinyl)-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]-2-methyl-1-piperazinyl]-

(R)-1-(4-(2-(2-Aminopyrimidin-5-yl)-6-morpholino-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl)-2-methylpiperazin-1-yl)ethan-1-one

1-[(2R)-4-[2-(2-aminopyrimidin-5-yl)-6-(morpholin-4-yl)-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]-2-methylpiperazin-1-yl]ethan-1-one

DS-7423, 10 mM in DMSO

1222104-37-1