ChemicalBook > CAS DataBase List > Tazemetostat hydrobromide

Tazemetostat hydrobromide

Product Name: Tazemetostat hydrobromide
CAS No.: 1467052-75-0
Chemical Name: Tazemetostat hydrobromide
Synonyms: Tazemetostat HBr;E-7438 hydrobromide;EPZ-6438 hydrobromide;Tazemetostat hydrobromide;Tazemetostat hydrobromide (JAN/USAN);Tazemetostat hydrobromide, 10 mM in DMSO;Tazemetostat HBr，Tazemetostat hydrobromide;Tazemetostat hydrobromide (EPZ6438 or E7438);Tazemetostat hydrobromide (EPZ-6438 hydrobromide);Tazemetostat,E 7438,E7438,PRC2,Inhibitor,E-7438,epigenetic,EZH2,EPZ6438,EPZ-6438,Histone Methyltransferase,cancer,Tazemetostat hydrobromide,EPZ 6438,inhibit,EZH1
CBNumber: CB14848188
Molecular Formula: C34H45BrN4O4
Formula Weight: 653.66
MOL File: 1467052-75-0.mol

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Tazemetostat hydrobromide Property

storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (152.99 mM)
InChIKey: UQRICAQPWZSJNF-UHFFFAOYSA-N
SMILES: N(C1CCOCC1)(C1C=C(C2C=CC(CN3CCOCC3)=CC=2)C=C(C(=O)NCC2C(NC(C)=CC=2C)=O)C=1C)CC.Br

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0101826
Product name: Tazemetostat(hydrobromide)
Purity: 99.18%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0101826
Product name: Tazemetostat(hydrobromide)
Purity: 99.18%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-0101826
Product name: Tazemetostat(hydrobromide)
Purity: 99.18%
Packaging: 50mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0101826
Product name: Tazemetostat(hydrobromide)
Purity: 99.18%
Packaging: 100mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0101826
Product name: Tazemetostat(hydrobromide)
Purity: 99.18%
Packaging: 200mg
Price: $290
Updated: 2021/12/16

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Tazemetostat hydrobromide Chemical Properties,Usage,Production

Uses

Tazemetostat Hydrobromide is developed by Epizyme for the treatment of relapsed or refractory follicular lymphoma.

brand name

Tazverik

Mechanism of action

Tazemetostat hydrobromide inhibits EZH2, affecting the epigenetic regulation of tumor cells, thereby inhibiting tumor growth.

Synthesis

Starting from 2-methyl-3-nitrobenzoic acid (366), dibromohydantoin (367) was used for bromination in sulfuric acid. Aniline 368 was generated through esterification and nitro group reduction in an overall yield of 81%. Aniline 368 was converted to dialkylarylamine 370 by two reductive amination reactions. The first reductive amination was performed with 4-oxoketone (369) and the second reductive amination was performed with acetaldehyde. The yield from 368 to 370 was 82%. Dialkylarylamine 370 was subjected to Suzuki coupling reaction with boric acid ester 371 and then saponification reaction to obtain compound 372 in two steps in an overall yield of 80%. The carboxylic acid of 372 was amide bonded with amine 373 under conventional conditions. Finally, the product was treated with aqueous hydrogen bromide to obtain tazostat hydrobromide in an overall yield of 75%.

Tazemetostat hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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1467052-75-0, Tazemetostat hydrobromideRelated Search:

Tazemetostat hydrobromide (JAN/USAN)

Tazemetostat hydrobromide

Tazemetostat hydrobromide (EPZ6438 or E7438)

E-7438 hydrobromide

EPZ-6438 hydrobromide

Tazemetostat HBr，Tazemetostat hydrobromide

Tazemetostat,E 7438,E7438,PRC2,Inhibitor,E-7438,epigenetic,EZH2,EPZ6438,EPZ-6438,Histone Methyltransferase,cancer,Tazemetostat hydrobromide,EPZ 6438,inhibit,EZH1

N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide hydrobromide

Tazemetostat hydrobromide (EPZ-6438 hydrobromide)

Tazemetostat HBr

Tazemetostat hydrobromide, 10 mM in DMSO

1467052-75-0

C34H44N4O4HBr