Tazemetostat hydrobromide
- Product Name
- Tazemetostat hydrobromide
- CAS No.
- 1467052-75-0
- Chemical Name
- Tazemetostat hydrobromide
- Synonyms
- Tazemetostat HBr;E-7438 hydrobromide;EPZ-6438 hydrobromide;Tazemetostat hydrobromide;Tazemetostat hydrobromide (JAN/USAN);Tazemetostat hydrobromide, 10 mM in DMSO;Tazemetostat HBr，Tazemetostat hydrobromide;Tazemetostat hydrobromide (EPZ6438 or E7438);Tazemetostat hydrobromide (EPZ-6438 hydrobromide);Tazemetostat,E 7438,E7438,PRC2,Inhibitor,E-7438,epigenetic,EZH2,EPZ6438,EPZ-6438,Histone Methyltransferase,cancer,Tazemetostat hydrobromide,EPZ 6438,inhibit,EZH1
- CBNumber
- CB14848188
- Molecular Formula
- C34H45BrN4O4
- Formula Weight
- 653.66
- MOL File
- 1467052-75-0.mol
Tazemetostat hydrobromide Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (152.99 mM)
- InChIKey
- UQRICAQPWZSJNF-UHFFFAOYSA-N
- SMILES
- N(C1CCOCC1)(C1C=C(C2C=CC(CN3CCOCC3)=CC=2)C=C(C(=O)NCC2C(NC(C)=CC=2C)=O)C=1C)CC.Br
N-Bromosuccinimide Price
- Product number
- CS-0101826
- Product name
- Tazemetostat(hydrobromide)
- Purity
- 99.18%
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0101826
- Product name
- Tazemetostat(hydrobromide)
- Purity
- 99.18%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-0101826
- Product name
- Tazemetostat(hydrobromide)
- Purity
- 99.18%
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0101826
- Product name
- Tazemetostat(hydrobromide)
- Purity
- 99.18%
- Packaging
- 100mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-0101826
- Product name
- Tazemetostat(hydrobromide)
- Purity
- 99.18%
- Packaging
- 200mg
- Price
- $290
- Updated
- 2021/12/16
Tazemetostat hydrobromide Chemical Properties,Usage,Production
Uses
Tazemetostat Hydrobromide is developed by Epizyme for the treatment of relapsed or refractory follicular lymphoma.
brand name
Tazverik
Mechanism of action
Tazemetostat hydrobromide inhibits EZH2, affecting the epigenetic regulation of tumor cells, thereby inhibiting tumor growth.
Synthesis
Starting from 2-methyl-3-nitrobenzoic acid (366), dibromohydantoin (367) was used for bromination in sulfuric acid. Aniline 368 was generated through esterification and nitro group reduction in an overall yield of 81%. Aniline 368 was converted to dialkylarylamine 370 by two reductive amination reactions. The first reductive amination was performed with 4-oxoketone (369) and the second reductive amination was performed with acetaldehyde. The yield from 368 to 370 was 82%. Dialkylarylamine 370 was subjected to Suzuki coupling reaction with boric acid ester 371 and then saponification reaction to obtain compound 372 in two steps in an overall yield of 80%. The carboxylic acid of 372 was amide bonded with amine 373 under conventional conditions. Finally, the product was treated with aqueous hydrogen bromide to obtain tazostat hydrobromide in an overall yield of 75%.
Tazemetostat hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
Tazemetostat hydrobromide Suppliers
- Tel
- +1-781-999-5354; +17819995354
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- Country
- United States
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