RA-9
- Product Name
- RA-9
- CAS No.
- 919091-63-7
- Chemical Name
- RA-9
- Synonyms
- RA-9 UPS inhibitor;RA-9, 10 mM in DMSO;(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)-;Unfolded,RA-9,cancer,RA 9,DUBs,Inhibitor,Apoptosis,Response,Deubiquitinase,cells,inhibit,Protein,ovarian,RA9,survival
- CBNumber
- CB16188329
- Molecular Formula
- C19H15N3O5
- Formula Weight
- 365.34
- MOL File
- 919091-63-7.mol
RA-9 Property
- Melting point:
- 230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8))
- Boiling point:
- 588.5±50.0 °C(Predicted)
- Density
- 1.414±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C)
- pka
- 5.13±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1206
- Product name
- RA-9
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $103
- Updated
- 2025/07/31
- Product number
- SML1206
- Product name
- RA-9
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $404
- Updated
- 2025/07/31
- Product number
- CS-0130075
- Product name
- RA-9
- Purity
- 98.12%
- Packaging
- 5mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-0130075
- Product name
- RA-9
- Purity
- 98.12%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CS-0130075
- Product name
- RA-9
- Purity
- 98.12%
- Packaging
- 50mg
- Price
- $240
- Updated
- 2021/12/16
RA-9 Chemical Properties,Usage,Production
Uses
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells[1].
Biological Activity
RA-9 is a potent and selective inhibitor of cell-permeable proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity and anticancer activity. It selectively induces apoptosis in ovarian cancer cell lines.
in vivo
RA-9 (5 mg/kg; ip; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.
| Six-week-old female immunodeficient (NCr nu/nu) mice | |
| Dosage: | 5 mg/kg |
| Administration: | Ip; one-day on, two-days off |
| Result: | Significant reduction in tumor burden at day 12. |
target
| Target | Value |
| DUBs () |