13(S)-HOTRE

13(S)-HOTRE Property

Boiling point:

431.5±30.0 °C(Predicted)

Density 

0.984±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml

pka

4.78±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

13(S)-HOTRE Chemical Properties,Usage,Production

Description

13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. It has been detected in cell membranes and as the cholesteryl ester associated with the lesions of atherosclerosis, and in the biomembranes of soybeans exposed to 15-LO.

Uses

13(S)-HOTrE is an ester product.

Definition

ChEBI: 13(S)-HOTrE is the (13S)-stereoisomer of HOTrE. It has a role as a mouse metabolite. It is a conjugate acid of a 13(S)-HOTrE(1-).

References

[1] JUTTA BELKNER . The oxygenation of cholesterol esters by the reticulocyte lipoxygenase[J]. FEBS Letters, 1991, 279 1: Pages 110-114. DOI: 10.1016/0014-5793(91)80263-3
[2] MAURO MACCARRONE. In vitro oxygenation of soybean biomembranes by lipoxygenase-2[J]. Biochimica et biophysica acta. Biomembranes, 1994, 1190 1: Pages 164-169. DOI: 10.1016/0005-2736(94)90046-9
[3] RACHEL E WALKER. Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers.[J]. ACS Applied Bio Materials, 2021: e14480. DOI: 10.14814/phy2.14480