FIDAS-5

Product Name: FIDAS-5
CAS No.: 1391934-98-7
Chemical Name: FIDAS-5
Synonyms: FIDAS-5;FIDAS-5, 10 mM in DMSO;(E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline;Benzenamine, 4-[(1E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methyl-;p21WAF1/CIP1,S-adenosylmethionine,inhibit,MAT2A,anti-proliferation,SAH,Inhibitor,FIDAS-5,anti-cancer,CyclinD1,FIDAS5,c-Myc,SAM,FIDAS 5,colorectal
CBNumber: CB18054404
Molecular Formula: C15H13ClFN
Formula Weight: 261.72
MOL File: 1391934-98-7.mol

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FIDAS-5 Property

Boiling point:: 385.1±30.0 °C(Predicted)
Density: 1.256±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 100mg/mL
form: Solid
pka: 4.44±0.38(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+
InChIKey: KXVXICBOMOGFMH-JXMROGBWSA-N
SMILES: C1(NC)=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0119760
Product name: FIDAS-5
Purity: 98.10%
Packaging: 5mg
Price: $145
Updated: 2021/12/16

ChemScene

Product number: CS-0119760
Product name: FIDAS-5
Purity: 98.10%
Packaging: 10mg
Price: $245
Updated: 2021/12/16

ChemScene

Product number: CS-0119760
Product name: FIDAS-5
Purity: 98.10%
Packaging: 50mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0119760
Product name: FIDAS-5
Purity: 98.10%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0119760
Product name: FIDAS-5
Purity: 98.10%
Packaging: 250mg
Price: $1350
Updated: 2021/12/16

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FIDAS-5 Chemical Properties,Usage,Production

Uses

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1].

Biological Activity

Cell permeable: yes', 'Primary Target
MAT2A', 'Reversible: yes

in vivo

FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight^[1].
Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced^[1].

Animal Model:	16 athymic nude mice injected with HT29 CRC cells^[1]
Dosage:	20 mg/kg
Administration:	Oral gavage; daily; for two weeks
Result:	Significantly inhibited the growth of xenograft tumors.

References

[1] Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. DOI:10.1021/cb3005353

FIDAS-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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FIDAS-5 Suppliers

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1391934-98-7, FIDAS-5Related Search:

FIDAS-5

(E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline

p21WAF1/CIP1,S-adenosylmethionine,inhibit,MAT2A,anti-proliferation,SAH,Inhibitor,FIDAS-5,anti-cancer,CyclinD1,FIDAS5,c-Myc,SAM,FIDAS 5,colorectal

Benzenamine, 4-[(1E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methyl-

FIDAS-5, 10 mM in DMSO

1391934-98-7