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FIDAS-5

Product Name
FIDAS-5
CAS No.
1391934-98-7
Chemical Name
FIDAS-5
Synonyms
FIDAS-5;FIDAS-5, 10 mM in DMSO;(E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline;Benzenamine, 4-[(1E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methyl-;p21WAF1/CIP1,S-adenosylmethionine,inhibit,MAT2A,anti-proliferation,SAH,Inhibitor,FIDAS-5,anti-cancer,CyclinD1,FIDAS5,c-Myc,SAM,FIDAS 5,colorectal
CBNumber
CB18054404
Molecular Formula
C15H13ClFN
Formula Weight
261.72
MOL File
1391934-98-7.mol
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FIDAS-5 Property

Boiling point:
385.1±30.0 °C(Predicted)
Density 
1.256±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 100mg/mL
form 
Solid
pka
4.44±0.38(Predicted)
color 
Light yellow to yellow
InChI
InChI=1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+
InChIKey
KXVXICBOMOGFMH-JXMROGBWSA-N
SMILES
C1(NC)=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0119760
Product name
FIDAS-5
Purity
98.10%
Packaging
5mg
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-0119760
Product name
FIDAS-5
Purity
98.10%
Packaging
10mg
Price
$245
Updated
2021/12/16
ChemScene
Product number
CS-0119760
Product name
FIDAS-5
Purity
98.10%
Packaging
50mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0119760
Product name
FIDAS-5
Purity
98.10%
Packaging
100mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0119760
Product name
FIDAS-5
Purity
98.10%
Packaging
250mg
Price
$1350
Updated
2021/12/16
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FIDAS-5 Chemical Properties,Usage,Production

Uses

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1].

Biological Activity

Cell permeable: yes', 'Primary Target
MAT2A', 'Reversible: yes

in vivo

FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight[1].
Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced[1].

Animal Model:16 athymic nude mice injected with HT29 CRC cells[1]
Dosage:20 mg/kg
Administration:Oral gavage; daily; for two weeks
Result:Significantly inhibited the growth of xenograft tumors.

References

[1] Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. DOI:10.1021/cb3005353

FIDAS-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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FIDAS-5 Suppliers

China 32 United States 4 Global 36
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58

1391934-98-7, FIDAS-5Related Search:


  • FIDAS-5
  • (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline
  • p21WAF1/CIP1,S-adenosylmethionine,inhibit,MAT2A,anti-proliferation,SAH,Inhibitor,FIDAS-5,anti-cancer,CyclinD1,FIDAS5,c-Myc,SAM,FIDAS 5,colorectal
  • Benzenamine, 4-[(1E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methyl-
  • FIDAS-5, 10 mM in DMSO
  • 1391934-98-7