Racotumomab

Product Name: Racotumomab
CAS No.: 946832-34-4
Chemical Name: Racotumomab
Synonyms: Racotumomab;Racotumomab (anti-GM3);Research Grade Racotumomab;Research Grade Racotumomab (DGK11201)
CBNumber: CB18080773
Formula Weight: 0
MOL File: Mol file

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Racotumomab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Racotumomab Chemical Properties,Usage,Production

Uses

Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer[1][2][3].

in vivo

Racotumomab (50 μg/dose, i.p.) together with Keyhole limpet hemocyanin (KLH) inhibits tumor growth in F3II cell (s.c.) mammary tumor mice model^[2].
Racotumomab (50 μg/dose, s.c.) together with Pemetrexed (100 mg/kg) is highly effective against lung nodules in 3LL cell (s.c.) mice xenograft^[3].
Racotumomab (50-200 μg/dose, s.c.) shows no significant antitumor effect in 3LL cell (s.c.) mice xenograft^[3].

Animal Model:	3LL cell (s.c.) mice xenograft^[3]
Dosage:	50 μg/dose, together with Pemetrexed (100 mg/kg)
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced lung nodules.

References

[1] Vázquez AM, et al. Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data. Front Oncol. 2012 Oct 23;2:150. DOI:10.3389/fonc.2012.00150
[2] Gajdosik Z. Racotumomab - a novel anti-idiotype monoclonal antibody vaccine for the treatment of cancer. Drugs Today (Barc). 2014 Apr;50(4):301-7. DOI:10.1358/dot.2014.50.4.2116670
[3] Segatori VI, et al. Preclinical evaluation of racotumomab, an anti-idiotype monoclonal antibody to N-glycolyl-containing gangliosides, with or without chemotherapy in a mouse model of non-small cell lung cancer. Front Oncol. 2012 Nov 8;2:160. DOI:10.3389/fonc.2012.00160
[4] Truong CS, et al. Oncolytic Vaccinia Virus in Lung Cancer Vaccines. Vaccines (Basel). 2022 Feb 4;10(2):240. DOI:10.3390/vaccines10020240

Racotumomab Preparation Products And Raw materials

Raw materials

Preparation Products

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Racotumomab Suppliers

China 18 United States 1 Global 19

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Racotumomab

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Research Grade Racotumomab

Racotumomab (anti-GM3)

946832-34-4