N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
Background- Product Name
- N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
- CAS No.
- 127243-85-0
- Chemical Name
- N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
- Synonyms
- H-89;CS-2385;H-89 hcl;H89 DIHCL;H-89 free base;H-89 ＆ H-89 2HCl;H-89 HYDROCHLORIDE;H-89 DIHYDROCHLORIDE;H-89 dihydrochloride,98%;Protein kinase inhibitor H-89
- CBNumber
- CB1853005
- Molecular Formula
- C20H20BrN3O2S
- Formula Weight
- 446.36
- MOL File
- 127243-85-0.mol
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Property
- Melting point:
- 195-200°C
- Boiling point:
- 639.7±65.0 °C(Predicted)
- Density
- 1.436
- storage temp.
- 2-8°C
- solubility
- H2O: ≥10 mg/mL
- form
- powder
- pka
- 10.43±0.50(Predicted)
- color
- off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
- Cosmetics Ingredients Functions
- SKIN CONDITIONING - MISCELLANEOUS
BLEACHING - CAS DataBase Reference
- 127243-85-0(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 371963-M
- Product name
- H-89, Dihydrochloride
- Purity
- A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (K<sub>i</sub> = 48 nM).
- Packaging
- 1 unit
- Price
- $157
- Updated
- 2025/07/31
- Product number
- 371962
- Product name
- H-89, Dihydrochloride
- Purity
- InSolution 10 mM, ≥99%, reversible ATP-competitive inhibitor of protein kinase A
- Packaging
- 1mg
- Price
- $163
- Updated
- 2025/07/31
- Product number
- H1660
- Product name
- H-89
- Packaging
- 10MG
- Price
- $140
- Updated
- 2025/07/31
- Product number
- H1660
- Product name
- H-89
- Packaging
- 50MG
- Price
- $420
- Updated
- 2025/07/31
- Product number
- 2910
- Product name
- H89dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $203
- Updated
- 2021/12/16
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA? IC50?= 140 nM).? Inhibits a variety of other kinases including S6K1 (IC50?= 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 μM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 μM).1,2
Chemical Properties
White Solid
Uses
Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM.
Definition
ChEBI: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]et ane-1,2-diamine.
General Description
A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 μM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 μM), protein kinase C (Ki = 31.7 μM), casein kinase I (Ki = 38.3 μM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 mM) by blocking the action of Rho kinase II.
Biological Activity
Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b).
Biochem/physiol Actions
Target Ki: 48 nM for protein kinase A
Background
H-89 is a potent selective inhibitor of cAMP dependent protein kinase. The in vitro IC50 of H-89 for PKA is approximately 50 nM and in vivo the inhibitiory effect on PKA substrate phosphorylation and related cellular functions range from 10 μM to 30 μM. In addition to PKA, H-89 also exhibits a moderate inhibitory effect on PKG and PKCμ, with IC50 in the 500 nM range. The inhibitory effect of H-89 is due to its competitive binding to the ATP pocket on the kinase catalytic subunit.
References
[1] A. LOCHNER J. A M. The Many Faces of H89: A Review[J]. Cardiovascular Therapeutics, 2007, 24 3-4: 261-274. DOI:10.1111/j.1527-3466.2006.00261.x
[2] JENNY BAIN. The selectivity of protein kinase inhibitors: a further update.[J]. Biochemical Journal, 2007: 297-315. DOI:10.1042/bj20070797
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE manufacturers
- Product
- H-89 dihydrochloride 127243-85-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-20