ChemicalBook > CAS DataBase List > N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

Product Name
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
CAS No.
127243-85-0
Chemical Name
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
Synonyms
H-89;CS-2385;H-89 hcl;H89 DIHCL;H-89 free base;H-89 ＆ H-89 2HCl;H-89 HYDROCHLORIDE;H-89 DIHYDROCHLORIDE;H-89 dihydrochloride,98%;Protein kinase inhibitor H-89
CBNumber
CB1853005
Molecular Formula
C20H20BrN3O2S
Formula Weight
446.36
MOL File
127243-85-0.mol
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N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Property

Melting point:
195-200°C
Boiling point:
639.7±65.0 °C(Predicted)
Density 
1.436
storage temp. 
2-8°C
solubility 
H2O: ≥10 mg/mL
form 
powder
pka
10.43±0.50(Predicted)
color 
off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference
127243-85-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
2910
Product name
H89dihydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$878
Updated
2021/12/16
Tocris
Product number
2910
Product name
H89dihydrochloride
Purity
≥98%(HPLC)
Packaging
1
Price
$93
Updated
2021/12/16
Tocris
Product number
2910
Product name
H89dihydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$203
Updated
2021/12/16
TRC
Product number
B682440
Product name
N-[2-(p-Bromocinnamylamino)ethyl]-5-IsoquinolineSulfonamide
Packaging
5mg
Price
$50
Updated
2021/12/16
Usbiological
Product number
P9104-35
Product name
Protein Kinase Inhibitor H-89
Packaging
10mg
Price
$375
Updated
2021/12/16
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N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA? IC50?= 140 nM).? Inhibits a variety of other kinases including S6K1 (IC50?= 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 μM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 μM).1,2

Chemical Properties

White Solid

Uses

Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM.

Definition

ChEBI: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]et ane-1,2-diamine.

General Description

A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 μM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 μM), protein kinase C (Ki = 31.7 μM), casein kinase I (Ki = 38.3 μM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 mM) by blocking the action of Rho kinase II.

Biological Activity

Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b).

Biochem/physiol Actions

Target Ki: 48 nM for protein kinase A

References

1) Lochner and Moolman (2006),?The many faces of H89: a review; Cardiovasc. Drugs,?24?261 2) Bain?et al. (2007),?The selectivity of protein kinase inhibitors: a further update; Biochem.J.?408(Pt3)?297

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Suppliers

Canada 1 China 86 Germany 2 India 1 South Korea 1 Switzerland 3 United Kingdom 6 United States 30 Global 130
Shanghai Boyle Chemical Co., Ltd.
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J & K SCIENTIFIC LTD.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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Adamas Reagent, Ltd.
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NCE Biomedical Co.,Ltd.
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AdooQ BioScience, LLC
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View Lastest Price from N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
H-89 dihydrochloride 127243-85-0
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-20

127243-85-0, N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDERelated Search:

ZM 447439 Imatinib mesylate Sunitinib Malate AICAR 4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE Propylamine H-89 DIHYDROCHLORIDE HYDRATE N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

  • H-89
  • H-89 DIHYDROCHLORIDE
  • H-89 HYDROCHLORIDE
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE
  • N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
  • N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE
  • H-89 dihydrochloride,98%
  • H89 DIHCL
  • N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride
  • H-89, Dihydrochloride Salt >99%
  • N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt
  • N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide
  • N-(2-((3-(4-BroMophenyl)allyl)aMino)ethyl)isoquinoline-5-sulfonaMide dihydrochloride
  • 5-IsoquinolinesulfonaMide,N-[2-[[3-(4-broMophenyl)-2-propen-1-yl]aMino]ethyl]-
  • Protein kinase inhibitor H-89
  • H-89 hcl
  • H-89 ＆ H-89 2HCl
  • N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
  • (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide
  • H-89 dihydrochloride, 98%, a potent and selective inhibitor of PKA
  • H 89 2HCl,H 89 dihydrochloride
  • H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
  • CS-2385
  • H 89 (Protein kinase inhibitor H-89
  • N-[2-[3-(4-bromophenyl)prop-2-enylamino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
  • N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLI
  • H-89 free base
  • 127243-85-0
  • C20H22BrN3O2SCl2
  • C20H22BrCl2N3O2S
  • C20H20BrN3O2S2HCl
  • C20H20BrN3O2S
  • C20H20BrN3O2S2ClH
  • Kinase/Phosphatase Biology
  • Protein Kinase A (PKA)
  • Serine/Threonine Kinase Inhibitors
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Inhibitor
  • Protein Kinase Inhibitors and Activators