GLP-1(7-37)Acetate

Product Name: GLP-1(7-37)Acetate
CAS No.: 1450806-98-0
Chemical Name: GLP-1(7-37)Acetate
Synonyms: GLP-1(7-37)Acetate;GLP-1(7-37) acetate(106612-94-6 free base);Inhibitor,inhibit,GCGR,Glucagon Receptor,GLP1(737) acetate(106612946 free base),GLP 1(7 37) acetate(106612 94 6 free base)
CBNumber: CB1953736
Molecular Formula: C153H232N40O49
Formula Weight: 3415.77
MOL File: 1450806-98-0.mol

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GLP-1(7-37)Acetate Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white
Sequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
InChIKey: YJIJUMYAXDUEKM-BVNXRIOCNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0089448
Product name: GLP-1(7-37)acetate
Purity: 98.65%
Packaging: 1mg
Price: $252
Updated: 2021/12/16

ChemScene

Product number: CS-0089448
Product name: GLP-1(7-37)acetate
Purity: 98.65%
Packaging: 5mg
Price: $432
Updated: 2021/12/16

ChemScene

Product number: CS-0089448
Product name: GLP-1(7-37)acetate
Purity: 98.65%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-0089448
Product name: GLP-1(7-37)acetate
Purity: 98.65%
Packaging: 25mg
Price: $1080
Updated: 2021/12/16

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GLP-1(7-37)Acetate Chemical Properties,Usage,Production

Description

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion[1].

GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats[2].Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM[2]. Animal Model: Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variablerate for 7 hours to maintain plasma glucose concentration at 11 mM[2].

Uses

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion[1].

in vivo

GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats^[2].
Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM^[2].

Animal Model:	Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable rate for 7 hours to maintain plasma glucose concentration at 11 mM^[2].
Dosage:	5 pmol/min/kg.
Administration:	IV from 1 hour through 7 hours^[2].
Result:	Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle.

Animal Model:	Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM^[2].
Dosage:	0.5, 5 or 50 pmol/min/kg.
Administration:	IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp.
Result:	Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.

References

[1]. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [2]. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7.

GLP-1(7-37)Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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1450806-98-0, GLP-1(7-37)AcetateRelated Search:

GLP-1(7-37)Acetate

GLP-1(7-37) acetate(106612-94-6 free base)

Inhibitor,inhibit,GCGR,Glucagon Receptor,GLP1(737) acetate(106612946 free base),GLP 1(7 37) acetate(106612 94 6 free base)

1450806-98-0