Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-

Product Name: Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-
CAS No.: 1268490-12-5
Chemical Name: Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-
Synonyms: GSK329;T24109;GSK-329;GSK 329;GSK329, 10 mM in DMSO;3-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-1-[3-(trifluoromethyl)phenyl]urea;N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N-[3-(trifluoromethyl)phenyl]-urea;Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-;diarylurea,cardiac-specific kinase,cardioprotective outcomes,inhibit,Inhibitor,GSK329,ischemia/reperfusion,TNNI3K
CBNumber: CB19816180
Molecular Formula: C19H14Cl2F3N5O2
Formula Weight: 472.25
MOL File: 1268490-12-5.mol

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Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Property

Boiling point:: 471.0±45.0 °C(Predicted)
Density: 1.554±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (529.38 mM; Need ultrasonic)
pka: 12.00±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Chemical Properties,Usage,Production

Uses

GSK329 is a potent and selective diarylurea inhibitor of the cardiac-specific kinase TNNI3K. GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury[1].

Biological Activity

GSK329 is a potent and selective diarylurea inhibitor of the cardiac-specific kinase TNNI3K. GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury[1].

storage

Store at -20°C

References

[1]. Patterson JR, et, al. Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf. J Med Chem. 2021 Nov 11;64(21):15651-15670.

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- Suppliers

China 30 United States 1 Global 31

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
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1268490-12-5, Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-Related Search:

Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]-

GSK 329

GSK329

GSK-329

T24109

diarylurea,cardiac-specific kinase,cardioprotective outcomes,inhibit,Inhibitor,GSK329,ischemia/reperfusion,TNNI3K

3-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-1-[3-(trifluoromethyl)phenyl]urea

GSK329, 10 mM in DMSO

N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N-[3-(trifluoromethyl)phenyl]-urea

1268490-12-5