CATHEPSIN L INHIBITOR I

Product Name: CATHEPSIN L INHIBITOR I
CAS No.: 105608-85-3
Chemical Name: CATHEPSIN L INHIBITOR I
Synonyms: Z-FF-FMK;CATHEPSIN L INHIBITOR I;Carbamic acid, N-[(1S)-2-[[(1S)-3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
CBNumber: CB2100326
Molecular Formula: C27H27FN2O4
Formula Weight: 462.51
MOL File: 105608-85-3.mol

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CATHEPSIN L INHIBITOR I Property

solubility: DMSO: Soluble: =10 mg/ml
form: Solid
color: White to off-white
Sequence: Z-Phe-Phe-FMK
InChIKey: CAILNONEKASNSH-ZEQRLZLVSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC1=CC=CC=C1)C(=O)CF)=O

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Hazard and Precautionary Statements (GHS)

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CATHEPSIN L INHIBITOR I Chemical Properties,Usage,Production

Uses

Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation[1].

References

[1] cathepsin-L DOI:10.1016/s0197-4580(03)00034-4
[2] ATSUSHI SHOJI . Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor[J]. Journal of pharmaceutical and biomedical analysis, 2017, 145: Pages 79-83. DOI: 10.1016/j.jpba.2017.06.026
[3] VIOLETA MORIN. Cathepsin L inhibitor I blocks mitotic chromosomes decondensation during cleavage cell cycles of sea urchin embryos.[J]. Journal of Cellular Physiology, 2008, 216 3: 790-795. DOI: 10.1002/jcp.21459
[4] YAN-RU WANG. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons.[J]. PLoS ONE, 2013: e75702. DOI: 10.1371/journal.pone.0075702

CATHEPSIN L INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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CATHEPSIN L INHIBITOR I Suppliers

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105608-85-3, CATHEPSIN L INHIBITOR IRelated Search:

Z-FF-FMK

CATHEPSIN L INHIBITOR I

Carbamic acid, N-[(1S)-2-[[(1S)-3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester

105608-85-3