CATHEPSIN L INHIBITOR I

CATHEPSIN L INHIBITOR I Property

solubility 

DMSO: Soluble: =10 mg/ml

form 

Solid

color 

White to off-white

Sequence

Z-Phe-Phe-FMK

InChIKey

CAILNONEKASNSH-ZEQRLZLVSA-N

SMILES

C(OCC1=CC=CC=C1)(=O)N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC1=CC=CC=C1)C(=O)CF)=O

Hazard and Precautionary Statements (GHS)

CATHEPSIN L INHIBITOR I Chemical Properties,Usage,Production

Uses

Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation[1].

References

[1] cathepsin-L DOI:10.1016/s0197-4580(03)00034-4
[2] ATSUSHI SHOJI . Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor[J]. Journal of pharmaceutical and biomedical analysis, 2017, 145: Pages 79-83. DOI: 10.1016/j.jpba.2017.06.026
[3] VIOLETA MORIN. Cathepsin L inhibitor I blocks mitotic chromosomes decondensation during cleavage cell cycles of sea urchin embryos.[J]. Journal of Cellular Physiology, 2008, 216 3: 790-795. DOI: 10.1002/jcp.21459
[4] YAN-RU WANG. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons.[J]. PLoS ONE, 2013: e75702. DOI: 10.1371/journal.pone.0075702