ChemicalBook > CAS DataBase List > Docarpamine
Docarpamine
- Product Name
- Docarpamine
- CAS No.
- 74639-40-0
- Chemical Name
- Docarpamine
- Synonyms
- TA 870;TA-8704;Tanadopa;Docarpamine;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
- CBNumber
- CB21178560
- Molecular Formula
- C21H30N2O8S
- Formula Weight
- 470.54
- MOL File
- 74639-40-0.mol
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Docarpamine Property
- Melting point:
- 85-90°; mp 105-108° (Nishiyama, 1992)
- alpha
- D20 -15.6° (c = 2 in methanol)
- Boiling point:
- 731.0±60.0 °C(Predicted)
- Density
- 1.222±0.06 g/cm3(Predicted)
- pka
- 14.51±0.46(Predicted)
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Safety
- Toxicity
- LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- API0002463
- Product name
- DOCARPAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.54
- Updated
- 2021/12/16
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Docarpamine Chemical Properties,Usage,Production
Description
Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.
Originator
Tanabe Seiyaku (Japan)
Uses
Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.
Definition
ChEBI: Docarpamine is an organic molecular entity.
brand name
Tanadopa
Docarpamine Preparation Products And Raw materials
Raw materials
Preparation Products
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