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Docarpamine

Product Name
Docarpamine
CAS No.
74639-40-0
Chemical Name
Docarpamine
Synonyms
TA 870;TA-8704;Tanadopa;Docarpamine;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
CBNumber
CB21178560
Molecular Formula
C21H30N2O8S
Formula Weight
470.54
MOL File
74639-40-0.mol
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Docarpamine Property

Melting point:
85-90°; mp 105-108° (Nishiyama, 1992)
alpha 
D20 -15.6° (c = 2 in methanol)
Boiling point:
731.0±60.0 °C(Predicted)
Density 
1.222±0.06 g/cm3(Predicted)
pka
14.51±0.46(Predicted)
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Safety

Toxicity
LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0002463
Product name
DOCARPAMINE
Purity
95.00%
Packaging
5MG
Price
$497.54
Updated
2021/12/16
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Docarpamine Chemical Properties,Usage,Production

Description

Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.

Originator

Tanabe Seiyaku (Japan)

Uses

Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.

Definition

ChEBI: Docarpamine is an organic molecular entity.

brand name

Tanadopa

Docarpamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Docarpamine Suppliers

China 9 United States 2 Global 11
RR Scientific LLC
Tel
+86-13917743231
Email
sales@rrscientific.com
Country
United States
ProdList
878
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58

74639-40-0, DocarpamineRelated Search:

N-[2-(4-methoxyphenyl)ethyl]-2-(methylamino)acetamide Docarpamine CARBONIC ACID ETHYL ESTER M-TOLYL ESTER

  • Docarpamine
  • Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
  • Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-
  • TA 870
  • Tanadopa
  • (S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide
  • 3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine
  • TA-8704
  • Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
  • 4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate
  • 74639-40-0
  • C21H30N2O8S