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DPPE FUMARATE

Product Name
DPPE FUMARATE
CAS No.
1185241-83-1
Chemical Name
DPPE FUMARATE
Synonyms
DPPE FUMARATE;Tesmilifene fumarate;DPPE fumarate Tesmilifene;Tesmilifene fumarate, 10 mM in DMSO;N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE;2-(4-Benzylphenoxy)-N,N-diethylethanamine 2-butenedioate(1:1);inhibit,anti-histaminic,Tesmilifene fumarate,DPPE,Histamine Receptor,seizure,Tesmilifene,chemotherapy,Inhibitor
CBNumber
CB2118466
Molecular Formula
C30H28O4P2
Formula Weight
514.49
MOL File
Mol file
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DPPE FUMARATE Property

storage temp. 
Desiccate at -20°C
solubility 
Soluble to 100 mM in sterile water
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
0743
Product name
DPPEfumarate
Packaging
10
Price
$104
Updated
2021/12/16
Tocris
Product number
0743
Product name
DPPEfumarate
Packaging
50
Price
$436
Updated
2021/12/16
TRC
Product number
D678883
Product name
DPPEFumarate
Packaging
1mg
Price
$70
Updated
2021/12/16
Usbiological
Product number
255194
Product name
DPPE fumarate
Packaging
10mg
Price
$389
Updated
2021/12/16
ApexBio Technology
Product number
B5014
Product name
DPPEfumarate
Packaging
10mg
Price
$203
Updated
2021/12/16
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DPPE FUMARATE Chemical Properties,Usage,Production

Uses

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

Biological Activity

Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor.? An inhibitor of histamine binding at the intracellular histamine (H lc ) site.

in vivo

Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2].

Animal Model:Male BKTO mice (25-45 g)[2].
Dosage:20 mg/kg (s.c.) and 20 μg (icv in 5 μL).
Administration:S.C. and icv.
Result:Potentiated seizures induced by both convulsants.

References

[1] Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. DOI:10.1016/j.mehy.2005.11.005
[2] G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9. DOI:10.1007/BF02007771

DPPE FUMARATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DPPE FUMARATE Suppliers

China 25 United Kingdom 2 United States 5 USA 1 Global 33
3B Pharmachem (Wuhan) International Co.,Ltd.
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1185241-83-1, DPPE FUMARATERelated Search:


  • N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE
  • DPPE FUMARATE
  • Tesmilifene fumarate
  • inhibit,anti-histaminic,Tesmilifene fumarate,DPPE,Histamine Receptor,seizure,Tesmilifene,chemotherapy,Inhibitor
  • 2-(4-Benzylphenoxy)-N,N-diethylethanamine 2-butenedioate(1:1)
  • DPPE fumarate Tesmilifene
  • Tesmilifene fumarate, 10 mM in DMSO
  • 1185241-83-1
  • C19H25NOC4H4O4
  • Histamine receptor