DPPE FUMARATE
- Product Name
- DPPE FUMARATE
- CAS No.
- 1185241-83-1
- Chemical Name
- DPPE FUMARATE
- Synonyms
- DPPE FUMARATE;Tesmilifene fumarate;DPPE fumarate Tesmilifene;Tesmilifene fumarate, 10 mM in DMSO;N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE;2-(4-Benzylphenoxy)-N,N-diethylethanamine 2-butenedioate(1:1);inhibit,anti-histaminic,Tesmilifene fumarate,DPPE,Histamine Receptor,seizure,Tesmilifene,chemotherapy,Inhibitor
- CBNumber
- CB2118466
- Molecular Formula
- C30H28O4P2
- Formula Weight
- 514.49
- MOL File
- Mol file
DPPE FUMARATE Property
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble to 100 mM in sterile water
- form
- Powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 0743
- Product name
- DPPEfumarate
- Packaging
- 10
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 0743
- Product name
- DPPEfumarate
- Packaging
- 50
- Price
- $436
- Updated
- 2021/12/16
- Product number
- D678883
- Product name
- DPPEFumarate
- Packaging
- 1mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 255194
- Product name
- DPPE fumarate
- Packaging
- 10mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- B5014
- Product name
- DPPEfumarate
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
DPPE FUMARATE Chemical Properties,Usage,Production
Uses
Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].
Biological Activity
Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor.? An inhibitor of histamine binding at the intracellular histamine (H lc ) site.
in vivo
Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2].
| Animal Model: | Male BKTO mice (25-45 g)[2]. |
| Dosage: | 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). |
| Administration: | S.C. and icv. |
| Result: | Potentiated seizures induced by both convulsants. |
References
[1] Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. DOI:10.1016/j.mehy.2005.11.005
[2] G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9. DOI:10.1007/BF02007771