ChemicalBook > CAS DataBase List > Doxorubicinone

Doxorubicinone

Product Name: Doxorubicinone
CAS No.: 24385-10-2
Chemical Name: Doxorubicinone
Synonyms: Ccris 7633;ADRIAMYCINONE;Doxorubicinone;Epirubicin aglycon;adriamycinaglycone;Epirubicin aglycone;Doxorubicin aglycone;Doxorubicinone-13C-D3;D2-N-Nitroso desmethyldoxycycline;Epirubicin Hydrochloride Impurity A
CBNumber: CB2121622
Molecular Formula: C21H18O9
Formula Weight: 414.36
MOL File: 24385-10-2.mol

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Doxorubicinone Property

Melting point:: 223-225°C
Boiling point:: 741.2±60.0 °C(Predicted)
Density: 1.671±0.06 g/cm3(Predicted)
storage temp.: Amber Vial, -20°C Freezer
solubility: Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 7.45±0.60(Predicted)
color: Red to Very Dark Red
Stability:: Light Sensitive
InChI: InChI=1S/C21H18O9/c1-30-11-4-2-3-8-14(11)20(28)16-15(17(8)25)18(26)9-5-21(29,12(24)7-22)6-10(23)13(9)19(16)27/h2-4,10,22-23,26-27,29H,5-7H2,1H3/t10-,21-/m0/s1
InChIKey: IBZGBXXTIGCACK-CWKPULSASA-N
SMILES: C1(OC)=C2C(C(=O)C3=C(C2=O)C(O)=C2C(C[C@@](O)(C(CO)=O)C[C@@H]2O)=C3O)=CC=C1
CAS DataBase Reference: 24385-10-2

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Safety

HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H340May cause genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21693
Product name: Doxorubicinone
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 21693
Product name: Doxorubicinone
Purity: ≥98%
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 21693
Product name: Doxorubicinone
Purity: ≥98%
Packaging: 5mg
Price: $601
Updated: 2024/03/01

Cayman Chemical

Product number: 21693
Product name: Doxorubicinone
Purity: ≥98%
Packaging: 10mg
Price: $1031
Updated: 2024/03/01

TRC

Product number: D559070
Product name: Doxorubicinone
Packaging: 50mg
Price: $1390
Updated: 2021/12/16

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Doxorubicinone Chemical Properties,Usage,Production

Description

Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin . Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner. Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes. It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner.

Chemical Properties

Red Solid

Uses

A metabolite of Doxorubicin (Dx).

Definition

ChEBI: Adriamycinone is a member of tetracenes and a quinone.

General Description

Doxorubicinone (adriamycinone) is an aglycone. It is a metabolite of adriamycin converted in the body, and another metabolite is amycinol [1]. Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis.

References

[1] Emara S, et al. Effect of cyclodextrins on the stability of adriamycin, adriamycinol, adriamycinone and daunomycin. Talanta, 2008; 51: 359-364.

Doxorubicinone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Doxorubicinone manufacturers

Moxin Chemicals

Product: Doxorubicin EP Impurity D 24385-10-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2025-03-19

R&D Scientific Inc.

Product: Doxorubicinone 24385-10-2
Price: US $2200.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 5 Kg
Release date: 2024-02-02

24385-10-2, DoxorubicinoneRelated Search:

Galarubicin hydrochloride Leurubicin Adriamycin Doxorubicinone Pirarubicin Nemorubicin Epirubicin EPIRUBICIN HYDROCHLORIDE 7-O-(2,6-Dideoxy-2-fluorotalopyranose)adriamycinone NAPHTHACENE N-trifluoroacetyladriamycin Esorubicin Detorubicin 7-O-(2,6-dideoxy-2-fluoro--5-C-(trifluoromethyl)talopyranosyl)adriamycinone N-(3-pyridylmethyl)adriamycin N,N-dimethyldoxorubicin N-trifluoroacetyladriamycin-14-O-hemiadipate 14-salicyloyldaunorubicin

Epirubicin aglycon

5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-

Ccris 7633

8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione

Doxorubicin aglycone

Doxorubicinone

Epirubicin aglycone

5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-

7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxy acetyl)-1-methoxy-(8S-cis)-5,12-naphthacenedione

ADRIAMYCINONE

(8S,10S)-7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy 8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

adriamycinaglycone

Doxorubicinone (Doxorubicin EP Impurity D,Epirubicin EP Impurity A)

5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-

Doxorubicin Hydrochloride EP Impurity D

Doxorubicinone-13C-D3

DoxorubicinoneQ: What is Doxorubicinone Q: What is the CAS Number of Doxorubicinone Q: What is the storage condition of Doxorubicinone Q: What are the applications of Doxorubicinone

Doxorubicinone ((8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetr (1225758)

(8S,10S)-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (doxorubicin aglycone, doxorubicinone).

(8S,10S)-10[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione,

Epirubicin Hydrochloride Impurity A

Doxorubicin EP Impurity D/Epirubicin hydrochloride EP impurity A

D2-N-Nitroso desmethyldoxycycline

(8S,10S)-6,8,10,11-Tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

(8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-dion

(8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-dione (Doxorubicin Aglycone, Doxorubicinone)

24385-10-2

C21H18O9

Intermediates & Fine Chemicals

Pharmaceuticals

Metabolites & Impurities

Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals