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squalamine

Product Name
squalamine
CAS No.
148717-90-2
Chemical Name
squalamine
Synonyms
MSI 1256;Squalamine, >98%;(3β，5α，7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7，24-diol-24-hydrogen sulfate;Cholestane-7,24-diol,3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3b,5a,7a,24R)-;Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
CBNumber
CB21321973
Molecular Formula
C34H65N3O5S
Formula Weight
627.96
MOL File
148717-90-2.mol
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squalamine Property

Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (159.25 mM)
form 
Solid
pka
-3.49±0.18(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4045
Product name
Squalamine
Purity
>98.0%
Packaging
1mg
Price
$600
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015537
Product name
SQUALAMINE
Purity
95.00%
Packaging
5MG
Price
$660
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS162105
Product name
Squalamine
Packaging
1mg
Price
$800
Updated
2021/12/16
ChemScene
Product number
CS-4045
Product name
Squalamine
Purity
>98.0%
Packaging
5mg
Price
$1140
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS162105
Product name
Squalamine
Packaging
2mg
Price
$1220
Updated
2021/12/16
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squalamine Chemical Properties,Usage,Production

Uses

Squalamine is an aminosterol broad-spectrum antibacterial drug present in shark tissue.

Definition

ChEBI: Squalamine is a bile acid.

Biological Activity

Squalamine (MSI-1256) is a compound with broad-spectrum antiviral activity.

Synthesis

Squalamine is isolated from the stomach of spiny horn shark and sea green dog shark.

in vivo

Squalamine (2 mg/kg; Intraperitoneal injection; 28 days) inhibits tumor growth in xenografted mice with breast cancer[2].
Squalamine (20 mg; Single application; 0-3 days) has a decolonizing effect on S. aureus on the skin in a mouse model[3].
Squalamine (20-120 mg/kg; Oral gavage; 5 days) restores the function of the mesenteric nervous system in PD mouse models[4].

Animal Model:Female athymic mice aged 6 weeks old bearing breast tumor xenografts[2]
Dosage:2 mg/kg
Administration:Intraperitoneal injection (i.p.); 28 days
Result:Significantly retarded the growth of tumors, but the combination with Trastuzumab (HY-P9907) was more effective.
Suppressed MCF-7/HER-2 breast xenograft-associated angiogenesis.
Animal Model:10 μL S. aureus suspension(108 cfu/mL) was applied to the female BALB/c mice skin[3]
Dosage:20 mg
Administration:Single application; 3 days
Result:Reduced S. aureus viable cells by up to 4 log after two days compared with the control.
Animal Model:PD mice models ( hSNCAA53T mice and PrP-A53T human α-syn overexpressing transgenic mice)[4]
Dosage:20, 40, 80, or 120 mg/kg
Administration:Oral gavage (i.g.); 5 days
Result:Effectively restored disordered colonic motility in PD mice models.
Increased colonic transit in PrP-A53T mice.
Reduced myenteric intrinsic primary afferent neuron excitability in hSNCAA53T mice.

squalamine Preparation Products And Raw materials

Raw materials

Chenodeoxycholic acid Dehydroepiandrosterone Fucosterol

Preparation Products

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squalamine Suppliers

China 30 India 1 United Kingdom 1 United States 5 Global 37
Artis Chemistry (Shanghai) Co. Ltd.
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86-21-60936353
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86-21-60936352
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China
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335
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NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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+86-27-87599188
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China
ProdList
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55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
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7552
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61
LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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China
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SPIRO PHARMA
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eric_feng1954@126.com
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China
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Jinan elephant international trading co., LTD
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13006575422@163.com
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China
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 18101056239
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3193328036@qq.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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Baoji Guokang Healthchem Co., Ltd.
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+86-0917-3909592 +86-13892490616
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09173909592
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gksales1@gk-bio.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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Absin Bioscience Inc.
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021-38015121 18438616290
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lanwu@univ-bio.com
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China
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Aleshan (Guangzhou) Biotechnology Co., Ltd
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18636736628
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Araratbio@163.com
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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58
TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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Chengdu Peter-like Biotechnology Co., Ltd.
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028-81700200 13308200041
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2851167782@qq.com
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China
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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Adooq Bioscience LLC
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400-025-6535
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sales@adooq.cn
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Zibo Hangyu Biotechnology Development Co., Ltd
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+86-0533-2185556 +8615965530500
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nickzhang@hangyubiotech.com
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RongNa Biotechnology Co.,Ltd
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+86-86-13583358881 +8618560316533
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Brad@rongnabiotech.com
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SHANGHAI KEAN TECHNOLOGY CO., LTD.
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+8613817748580
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021-50175322
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Shanghai Acmec Biochemical Technology Co., Ltd.
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+86-18621343501; +undefined18621343501
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product@acmec-e.com
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PT CHEM GROUP LIMITED
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+86-85511178;
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China
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Guangzhou Kele Biotechnology Co., Ltd.
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18924239974
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CHINA
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Guangzhou Kati Biotechnology Co., Ltd.
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13128698830
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Shanghai Machine Pure Industrial Co., Ltd.
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3245176082@qq.com
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Shanghai Wowu Biological Technology Co., Ltd.
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Shanghai Jinsui Biological Technology Co., Ltd.
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1426662382@qq.com
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View Lastest Price from squalamine manufacturers

RongNa Biotechnology Co.,Ltd
Product
squalamine 148717-90-2
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
1 ton
Release date
2025-08-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
Squalamine 148717-90-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Squalamine 148717-90-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

148717-90-2, squalamineRelated Search:

N-(3-AMINOPROPYL)CYCLOHEXYLAMINE N-cyclodecylmethylamine squalamine

  • (3β，5α，7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7，24-diol-24-hydrogen sulfate
  • MSI 1256
  • Squalamine, >98%
  • Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
  • Cholestane-7,24-diol,3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3b,5a,7a,24R)-
  • 148717-90-2
  • C34H65N3O5S
  • C34H67N3O5S